Results 91 to 100 of about 914,661 (291)

Chimeric Antigen Receptor (CAR) T-Cell Therapy Use in Patients with Multiple Myeloma and Kidney Failure on Maintenance Hemodialysis: A Report of 2 Cases

Kidney Medicine
Chimeric antigen receptor (CAR) T-cell therapy against B-cell maturation antigen is a new treatment modality for relapsed or refractory multiple myeloma (MM).
Wai Lun Will Pak, Natalie A. Brumwell, Charlene C. Kabel, Victoria Gutgarts, Insara Jaffer Sathick, Sham Mailankody, Alexander M. Lesokhin, Heather J. Landau, Aisha Shaikh   +8 more
doaj   +1 more source

Clinical case of oropharyngeal metastasis of kidney cancer

Опухоли головы и шеи, 2018
Oropharyngeal metastases are very rare and occur in approximately 1.0–1.5 % of all malignant tumors of the oral cavity and oropharynx. Information on oropharyngeal localization of metastases of kidney cancer is almost absent in the literature.
Т. А. Aketova, R. I. Azizyan, S. D. Bezhanova, А. А. Zotova, V. Zh. Brzhezovskiy   +4 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Critical care provision after colorectal cancer surgery [PDF]

, 2016
Background: Colorectal cancer (CRC) is the 2nd largest cause of cancer related mortality in the UK with 40 000 new patients being diagnosed each year. Complications of CRC surgery can occur in the perioperative period that leads to the requirement of ...
Dale, C.D., Kinsella, J., McLoone, P., Morrison, D., Puxty, K., Quasim, T., Sloan, B.   +6 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Transplant Glomerulopathy: The Interaction of HLA Antibodies and Endothelium

Journal of Immunology Research, 2014
Transplant glomerulopathy (TG) is a major cause of chronic graft dysfunction without effective therapy. Although the histological definition of TG is well characterized, the pathophysiological pathways leading to TG development are still poorly ...
William Hanf, Claudine S. Bonder, P. Toby H. Coates   +2 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma

Nature Communications
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking.
Richard Culliford, Samuel E. D. Lawrence, Charlie Mills, Zayd Tippu, Daniel Chubb, Alex J. Cornish, Lisa Browning, Ben Kinnersley, Robert Bentham, Amit Sud, Husayn Pallikonda, The Renal Cancer Genomics England Consortium, Anna Frangou, Andreas J. Gruber, Kevin Litchfield, David Wedge, James Larkin, Samra Turajlic, Richard S. Houlston   +18 more
doaj   +1 more source

Chinese quality control indices for standardized diagnosis and treatment of renal cancer (2022 edition)

Journal of the National Cancer Center
Renal cancer is one of the most common malignancies of the urinary system, and the number of deaths continues to increase. The standardized management of the diagnosis and treatment of renal cancer is challenging due to the great differences in the ...
Lin Yao, Yicong Du, Wen Dong, Xianshu Gao, Jun Guo, Jianxing Qiu, Qiang Wei, Shikai Wu, Dingwei Ye, Wei Yu, Hao Zeng, Qian Zhang, Yong Zhang, Zhiling Zhang, Fangjian Zhou, Wenjing Yang, Hui Wang, Xu Zhang, Zhisong He   +18 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source