Results 161 to 170 of about 591,781 (298)

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

TCOF1 affects Golgi secretory pathway contributing to the angiogenesis in renal cancer. [PDF]

Cell Commun Signal
Grzanka M, Popławski P, Wiśniewski JR, Iwanicka-Nowicka R, Kossowska H, Koblowska M, Rybicka B, Białas A, Piekiełko-Witkowska A.   +8 more
europepmc   +1 more source

Hypoxia regulated pathways in urological malignancies

, 2009
Introduction: Kidney Cancer accounts for approximately 2% of all new cancer diagnoses inthe UK each year. Patient survival has improved over the past few decades; however themechanisms of this are yet to be fully elucidated.
Charlesworth, Philip J.S., Charlesworth, Philip J S   +1 more
core  

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, EarlyView.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

Trends in artificial intelligence and machine learning for renal cancer. [PDF]

Discov Oncol
Xi Z, Niu J, Dong Z, Xing Z, Yu Y, Yu S, Kang J.   +6 more
europepmc   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Yusuke Nakamura, Tomomi Ueki, Miki Akiyama, Meng-Lay Lin, Arata Shimo, Jae-Hyun Park, Yataro Daigo, Toyomasa Katagiri, Tatsuhiko Tsunoda, Jung-Won Kim, Toshihiko Nishidate   +10 more
core  

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Impact of Perioperative Proton Pump Inhibitors on Renal Cancer Progression. A Retrospective Study. [PDF]

Cancer Med
Cortes-Mejia N, Wong R, Eltzschig HK, Moreno-Lopez SM, Bejarano-Ramirez D, Huang H, Cata JP.   +6 more
europepmc   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

CXCR4, CXCR7 and PBRM1 are responsible for everolimus and cabozantinib resistance in human renal cancer cells. [PDF]

Cell Death Discov
Auletta F, Ieranò C, Di Febbraro DG, Bello AM, Rea G, Napolitano M, Galdiero F, Guardascione G, Trotta AM, Santagata S, Vetrei C, Di Maiolo G, Russo D, Spina A, D'Alterio C, Portella L, Ascrizzi S, Scaglione GL, Tassone P, Di Martino MT, Scala S.   +20 more
europepmc   +1 more source