Results 191 to 200 of about 357,421 (301)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Use of the Ion Robot in the Diagnosis of Pulmonary Nodules: Fine Needle Aspiration Versus Cryobiopsy

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Robotic‐assisted bronchoscopy platforms provide an innovative approach to the sampling of pulmonary nodules. As compared to other technologies, fiber‐optic shape‐sensing instrumentation allows for a more precise, accurate location and sampling of the target lesion with fewer complications.
Suzanne M. Selvaggi
wiley   +1 more source

The IQGAP1-Claudin4-JNK Signaling Axis as a Differential Biomarker in Renal Cell Carcinoma. [PDF]

Clin Transl Sci
Puente N, Fan X, Nadiminty N, Ekwenna O, Petros FG, Sindhwani P, Gohara A, Yakirevich E, Osman MA.   +8 more
europepmc   +1 more source

Fibromyxoid Nephrogenic Adenoma Mimicking Renal Cell Carcinoma: A Diagnostic Pitfall in Fine‐Needle Aspiration Cytology

Diagnostic Cytopathology, EarlyView.
ABSTRACT Nephrogenic adenoma (NA) is a benign lesion of the genitourinary tract that may mimic malignancy both clinically and histologically. The fibromyxoid variant (FMNA), characterized by spindled cells in myxoid stroma, presents additional diagnostic challenges due to its rarity and overlapping features with renal cell carcinoma (RCC).
Jodi Gedallovich, Adebola Adeniyi, Ankur R. Sangoi, Xiaohua Qian, Kelly Ernst   +4 more
wiley   +1 more source

1H MR-based detection of human plasma metabolic alterations in clear cell renal cell carcinoma. [PDF]

BJUI Compass
Sharma RK, Solaiyappan M, Feinaj A, Brönimann S, Singla N, Bhujwalla ZM, Ged Y.   +6 more
europepmc   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Histologic Heterogeneity of Metastases in Clear Cell Renal Cell Carcinoma with Sarcomatoid Differentiation. [PDF]

J Clin Med
Berry K, Skelton WP, Karabinus M, Monda S, Tandon R, Frierson H, May AM.   +6 more
europepmc   +1 more source

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

Aging is associated with the outcomes of immune checkpoint blockade in renal cell carcinoma. [PDF]

J Immunother Cancer
Huang Z, Zhou J, Zheng Z, Zhao H, Zhao B, Zeng R.   +5 more
europepmc   +1 more source

Renal venography in renal cell carcinoma [PDF]

American Journal of Roentgenology, 1980
openaire   +2 more sources