Results 211 to 220 of about 577,818 (354)

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis

Advanced Science, EarlyView.
SeZM NPs selectively target M2b macrophages through mannose–MRC1 (CD206) recognition, enhance GPX1 biosynthesis, and suppress mitochondrial ROS generation, oxidative stress, and JAK–STAT signaling. This dual regulation reduces pro‐inflammatory cytokine release, limits immune cell infiltration and fibrosis, and preserves renal function, providing a ...
Haoran Lv, Guanning Huang, Hongyu Li, Hanzhi Liang, Huajing Peng, Kefei Wu, Wenfang Chen, Dandan Zhang, Kexin Ma, Yufei Du, Siweier Luo, Yi Zhou, Haiping Mao, Wei Chen, Tianfeng Chen, Yiming Zhou, Qinghua Liu   +16 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

A Rare Case of Renal Cell Carcinoma Metastasis to the Coracoid Process. [PDF]

Cureus
Patel M, Deshpande A.
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Clinical and Molecular Characterization of KRAS-Mutated Renal Cell Carcinoma. [PDF]

Cancers (Basel)
Lopez Sanmiguel A, Khandwala YS, Fengshen K, Dawidek M, Tse E, Barbakoff D, Posada Calderon L, Carlo MI, Coleman J, Russo P, Tickoo SK, Reuter VE, Reznik E, Chen YB, Hakimi AA.   +14 more
europepmc   +1 more source

Decadal Experience of Renal Cell Carcinoma from a Tertiary Care Teaching Institute in North India [PDF]

, 2018
Kawaljit Singh, Sinha Rahul Janak, Gupta Ashok, Vishwajeet Singh   +3 more
openalex   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source

Deciphering genetic susceptibility to clear cell renal cell carcinoma. [PDF]

Commun Biol
Mandelia M, Law PJ, Mills C, Went M, Vijayakrishnan J, Houlston RS.   +5 more
europepmc   +1 more source

Computed tomography and magnetic resonance findings of fat-poor angiomyolipomas [PDF]

, 2017
Bauman, Tyler M, Figenshau, Robert Sherburne, Knight, B. Alexander, Mobley, Jonathan M, Park, Alyssa M, Potretzke, Aaron M, Potretzke, Theodora A, Siegel, Cary Lynn   +7 more
core   +2 more sources