Results 51 to 60 of about 1,140,223 (331)

Metastatic renal cell carcinoma initially presenting with hematochezia and subsequently with vaginal bleeding: a case report

BMC Urology, 2018
Background We report an unusual case of a synchronous rectal and metachronous vaginal metastatic renal cell carcinoma. Case presentation A 78-year-old woman presented with hematochezia and a colonoscopy revealed a metastatic clear-cell renal cell ...
Simon Ouellet, Audrey Binette, Alexander Nguyen, Perrine Garde-Granger, Robert Sabbagh   +4 more
doaj   +1 more source

Double renal cell carcinoma with histological type of clear cell carcinoma and papillary carcinoma in the same kidney concurrently treated with robot‐assisted partial nephrectomy

IJU Case Reports, 2022
Introduction The presence of two different histologic types of renal cell carcinoma in the same kidney is rare in clinical practice. This report describes a patient with ipsilateral renal cell carcinomas, consisting of a clear cell renal cell carcinoma ...
Teruki Shimizu, Fumiya Hongo, Hikaru Takahashi, Atsuko Fujihara, Osamu Ukimura   +4 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Unusual head and neck presentation of metastatic renal cell carcinoma

Otolaryngology Case Reports, 2023
Skull base metastasis from renal cell carcinoma are exceedingly rare. Though renal cell carcinoma often presents at an advanced stage and with metastasis, signs and symptoms of skull base involvement would rarely suggest renal cell carcinoma.
Kyle J. Kozak, Tibor Valyi-Nagy, Jeffrey W. Yu   +2 more
doaj  

Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma

Frontiers in Genetics, 2023
Background: Cytoskeleton-associated protein 2-like protein (CKAP2L) is thought to promote the progression of glioma, breast cancer, and ovarian cancer. However, the role of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma
Zhi Liu, Jun Zhang, Deyun Shen, Xuechun Hu, Zongpan Ke, I Nyoman Ehrich Lister, Bungaran Sihombing   +6 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Renal cell carcinoma with melanin pigment

Indian Journal of Urology, 2010
The incidence of renal cell carcinoma has been steadily increasing. There are several morphological types of renal cell carcinoma. Recognizing histologic patterns of renal cell carcinoma is important for correct diagnosis and subsequent medical care for ...
Jayaprakash Shetty, Chandrika, Prabhu Laxman   +2 more
doaj   +1 more source

Intravascular large B‐cell lymphoma in renal cell carcinoma incidentally detected by robot‐assisted partial nephrectomy

IJU Case Reports, 2022
Introduction Intravascular large B‐cell lymphoma is a rare and aggressive type of extranodal large B‐cell lymphoma. Although intravascular large B‐cell lymphoma can invade various organs, renal involvement has been rarely reported. Synchronous occurrence
Michio Noda, Yutaka Enomoto, Yukari Shirasugi, Sumiyo Ando, Yukimasa Matsuzawa, Haruki Kume   +5 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A Case of Sarcomatoid Renal Cell Carcinoma With Osseous Metaplasia and Papillary Renal Cell Carcinoma Metastasis

Clinical Pathology, 2019
Sarcomatoid renal cell carcinoma is an uncommon and aggressive renal tumor with rapid disease progression. A median survival time is only 4-9 months after diagnosis. Osteogenic differentiation is a rare feature of the tumor.
Hui Zhang, Nasma K Majeed, Roohollah Sharifi, Grace Guzman   +3 more
doaj   +1 more source