Results 41 to 50 of about 653,483 (216)

The Renal Nerves in Chronic Heart Failure: Afferent and Efferent Mechanisms

Frontiers in Physiology, 2015
The function of the renal nerves has been an area of scientific and medical interest for many years. The recent advent of a minimally invasive catheter-based method of renal denervation has renewed excitement in understanding the afferent and efferent ...
Alicia Marie Schiller, Peter Ricci Pellegrino, Irving H Zucker   +2 more
doaj   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Renal Denervation in Heart Failure: A New Therapeutic Paradigm

, 2015
Heart failure constitutes a significant source of morbidity and mortality in the United States, and its incidence and prevalence continue to grow, increasing its burden on the health care system. Renal dysfunction in patients with heart failure is common
Hani Kozman, Kan Liu, Robert L. Carhart Jr., Pramesh Dhakal, Daniel Villarreal   +4 more
core   +1 more source

Attenuation of Splanchnic Autotransfusion Following Noninvasive Ultrasound Renal Denervation: A Novel Marker of Procedural Success

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Renal denervation has no validated marker of procedural success. We hypothesized that successful renal denervation would reduce renal sympathetic nerve signaling demonstrated by attenuation of α‐1‐adrenoceptor‐mediated autotransfusion during ...
Manish Saxena, Tariq Shour, Mussadiq Shah, Christopher B. Wolff, Peter O. O. Julu, Vikas Kapil, David J. Collier, Fu Liang Ng, Ajay Gupta, Armida Balawon, Jane Pheby, Anne Zak, Gurvinder Rull, Benjamin O'Brien, Roland E. Schmieder, Melvin D. Lobo   +15 more
doaj   +1 more source

Metabolic Effects of Renal Denervation

Current Clinical Pharmacology, 2013
In the present review article we address the issue of the potential effect of renal sympathetic denervation (RSD) on metabolic states associated with resistant hypertension. So far, there is an established pathophysiological background denoting that abnormalities in glucose metabolism especially in obese patients and in those with sleep apnea are ...
Thomopoulos, C., Spanoudi, F., Kyriazis, I., Anastasopoulos, I., Ioannidis, I.   +4 more
openaire   +3 more sources

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Unilateral renal sympathetic denervation may reduce blood pressure in patients with refractory hypertension

Italian Journal of Medicine, 2015
A 52-year-old Caucasian woman with essential resistant and refractory hypertension despite optimal medical therapy, including 6 different antihypertensive drugs was referred for the catheter-based renal denervation. Due to unfavourable anatomy because of
Aurelio Negro, Rosaria Santi, Antonio Manari, Franco Perazzoli   +3 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Geometrical changes after renal denervation.

, 2015
Geometrical changes after renal denervation.
Ronald L. A. W. Bleys (828880), Willemien L. Verloop (690472), Roel Goldschmeding (50835), Lisette E. G. Hubens (828879), Wilko Spiering (590722), Michiel Voskuil (690475), Pieter A. Doevendans (137859)   +6 more
core   +1 more source

Quantification of Renal Sympathetic Vasomotion as a Novel End Point for Renal Denervation

, 2020
Renal sympathetic denervation, a potentially revolutionary interventional treatment for hypertension, faces an existential problem due to the inability to confirm successful ablation of the targeted renal sympathetic nerves. Based on the observation that
Wang, Han-Jun, Schiller, Alicia M., Pellegrino, Peter Ricci, Zucker, Irving H., Chatzizisis, Ioannis, Alicia M. Schiller, Irving H. Zucker, Yiannis S. Chatzizisis, Peter Ricci Pellegrino, Han-Jun Wang   +9 more
core   +1 more source