Results 61 to 70 of about 10,774 (174)

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension

International Journal of Hypertension, 2011
Hypertension represents a major health problem with an appalling annual toll. Despite the plethora of antihypertensive drugs, hypertension remains resistant in a considerable number of patients, thus creating the need for alternative strategies ...
Vasilios Papademetriou, Michalis Doumas, Konstantinos Tsioufis   +2 more
doaj   +1 more source

Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation

Патология кровообращения и кардиохирургия, 2016
Objective. The aim of this prospective randomized study was to assess the impact of renal artery denervation on patients with refractory AF and drug resistant hypertension, for whom pulmonary vein isolation (PVI) was recommended.Methods.
Д. А. Заманов, А. Ю. Дмитриев, С. И. Антонов, Л. В. Пристромова, Э. Э. Иваницкая, А. В. Пустовойтов, Е. Е. Корчагин, С. Н. Артеменко, В. В. Шабанов, А. Б. Романов, Е. А. Покушалов   +10 more
doaj   +1 more source

Immune‐Related Polyradiculoneuropathy Associated With Immune Checkpoint Inhibitors: A Comprehensive Case Series

Brain and Behavior, Volume 16, Issue 5, May 2026.
ABSTRACT Objective Immune‐related polyradiculoneuropathy (irPRN) is a rare but potentially severe neurological adverse event secondary to immune checkpoint inhibitors (ICIs), closely resembling Guillain–Barré syndrome. This study aims to characterize the clinical presentation, neurophysiological findings, therapeutic strategies, and clinical outcomes ...
A. Llauradó, E. Lainez, H. Ariño, M. Gratacòs‐Viñola, J. L. Seoane, M. Roca‐Herrera, J. L. Restrepo‐Vera, D. Sanchez‐Tejerina, N. Raguer, R. Juntas‐Morales   +9 more
wiley   +1 more source

Acute Intermittent Porphyria Triggered by COVID‐19 Mimicking Guillain–Barré Syndrome: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Acute intermittent porphyria (AIP) is a rare heme biosynthesis disorder in which the accumulation of neurotoxic porphyrin precursors precipitates neurovisceral attacks. Intercurrent infections, including coronavirus disease 2019 (COVID‐19), may trigger or exacerbate AIP and complicate diagnosis, as clinical manifestations can resemble those of
Payman Sadeghi, Masood Ghahvechi Akbari, Seyed Abbas Hassani, Hosein Alimadadi, Morteza Heidari, Vahid Ziaee   +5 more
wiley   +1 more source

Robot-assisted renal denervation as a new surgical approach for therapy resistant arterial hypertension

Urology Case Reports
Arterial hypertension is a major cause of mortality and morbidity worldwide. Medical therapy is the most common treatment. However, in some cases there is a persistent high blood pressure despite medical therapy. These patients with medication refractory
Sarah Rosier, Robby Lamoury, Koen Ameloot, Robbe Knaepen, Thomas De Sutter, Hans Goethuys, Yannic Raskin   +6 more
doaj   +1 more source

RENAL DENERVATION: IMPACT OF ANATOMY ON PROCEDURE OUTCOME

Фундаментальная и клиническая медицина, 2018
Aim. To evaluate early and long-term results of renal denervation in patients with resistant arterial hypertension and different anatomy of renal arter-ies as compared to those who underwent a conser-vative treatment.Materials and Methods.
TATIANA Y. Chichkova, SERGEY E. Mamchur, MARIA P. Romanova, EGOR A. Khomenko, ALEXANDR Y. Ivanov   +4 more
doaj  

Renal Denervation of Accessory Renal Arteries

JACC: Cardiovascular Interventions, 2014
In the October issue of JACC: Cardiovascular Interventions , Id et al. [(1)][1] compared the results of renal denervation using the Symplicity catheter system (Medtronic, Mountain View, California) in patients with and without accessory renal arteries.
openaire   +2 more sources

Renal Denervation: Past, Present, and Future

Cardiovascular Innovations and Applications, 2016
Over the past decade, percutaneous renal denervation has been vigorously investigated as a treatment for resistant hypertension. The SYMPLICITY radiofrequency catheter system (Medtronic CardioVascular Inc., Santa Rosa, CA, USA) is the most tested device ...
Negiin Pourafshar, Ashkan Karimi, R. David Anderson, Seyed Hossein Alaei-Andabili, David E. Kandzari   +4 more
doaj   +1 more source