Results 61 to 70 of about 1,206,636 (268)

Hypertension and Renal Disease

Renal Failure, 1993
Chronic renal parenchymal disease is the most common cause of secondary hypertension: By the time end-stage renal disease develops, its prevalence approaches 75-85%. It was previously believed that hypertension caused arteriolar nephrosclerosis and ischemic renal injury superimposed on primary renal parenchymal disease, contributing to progressive ...
G A, Cinotti, C, Comunian
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Clinical implications of pathological features of primary membranous nephropathy

BMC Nephrology, 2018
Background The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, persistent elevation of anti-PLA2R ...
Xiao-dan Zhang, Zhao Cui, Mu-fan Zhang, Jia Wang, Yi-miao Zhang, Zhen Qu, Xin Wang, Jing Huang, Fang Wang, Li-qiang Meng, Xu-yang Cheng, Su-xia Wang, Gang Liu, Ming-hui Zhao   +13 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Safety incidents during intrahospital transport of hemodialysis patients in China: a multicenter cross-sectional study

Frontiers in Public Health
ObjectiveTo characterize safety incidents during intrahospital transport of hemodialysis patients in Chinese tertiary hospitals to guide evidence-based safety standards.MethodsA multicenter cross-sectional study (STROBE-guided) included 4,253 registered ...
Jing Li, Jing Li, Jing Li, Jing Li, Yao Liu, Yao Liu, Yao Liu, Yao Liu, Liyun Cao, Liyun Cao, Liyun Cao, Liyun Cao, Meng Zhao, Meng Zhao, Meng Zhao, Meng Zhao, Huipeng Xing, Huipeng Xing, Huipeng Xing, Huipeng Xing, Yinbilige Se, Yinbilige Se, Yinbilige Se, Yinbilige Se, Yuqing Chen, Yuqing Chen, Yuqing Chen, Yuqing Chen   +27 more
doaj   +1 more source

Autophagy in Immune-Related Renal Disease

Journal of Immunology Research, 2019
Autophagy is an important biology process, central to the maintenance of biology process in both physiological and pathological situations. It is regarded as a “double-edged sword”—exerting both protective and/or detrimental effects.
Xin Ye, Xu-jie Zhou, Hong Zhang
doaj   +1 more source

Epidemiology of acute kidney injury in hospitalized pregnant women in China

BMC Nephrology, 2019
Background Epidemiologic data of acute kidney injury (AKI) during pregnancy is lacking in China. This study aims to determine the effect of pregnancy on the risk of AKI among hospitalized women of childbearing age, and to describe the incidence, risk ...
Diankun Liu, Wenjuan He, Yanqin Li, Mengqi Xiong, Long Wang, Jingxin Huang, Ling Jia, Shuling Yuan, Sheng Nie   +8 more
doaj   +1 more source

Lipids and Renal Disease

Methodist DeBakey Cardiovascular Journal, 2019
The column in this issue is supplied by Anita Shah, M.D., and Juan Jose Olivero, M.D. Dr. Shah is a first-year nephrology fellow at Baylor College of Medicine in Houston, Texas. She earned her medical degree from The University of Texas Medical Branch at Galveston and completed an internal medicine residency at Houston Methodist Hospital. Dr.
Anita, Shah, Juan Jose, Olivero
openaire   +2 more sources