Results 61 to 70 of about 1,430,825 (310)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Revascularization as a treatment to improve renal function

International Journal of Nephrology and Renovascular Disease, 2014
Helen V Alderson, James P Ritchie, Philip A Kalra The University of Manchester, Manchester Academic Health Sciences Centre, Vascular Research Group, Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford, UK Abstract: An aging ...
Alderson HV, Ritchie JP, Kalra PA
doaj  

Predictive abilities of cardiovascular biomarkers to rapid decline of renal function in Chinese community-dwelling population: a 5-year prospective analysis

BMC Nephrology, 2017
Background Predictive abilities of cardiovascular biomarkers to renal function decline are more significant in Chinese community-dwelling population without glomerular filtration rate (GFR) below 60 ml/min/1.73m2, and long-term prospective study is an ...
Shihui Fu, Chunling Liu, Leiming Luo, Ping Ye   +3 more
doaj   +1 more source

Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment [PDF]

, 2003
Introduction: This open label, multicentre study was conducted to assess the times to offset of the pharmacodynamic effects and the safety of remifentanil in patients with varying degrees of renal impairment requiring intensive care. Methods: A total of
Breen, Des, Wilmer, Alexander, Bodenham, Andrew, Bach, Vagn, Bonde, Jan, Kessler, Paul, Albrecht, Sven, Shaikh, Soraya   +7 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Improvement of renal function after transcatheter aortic valve replacement in patients with chronic kidney disease.

PLoS ONE, 2021
BackgroundChronic kidney disease is commonly found in patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) and has marked impact in their prognosis.
Michel V Lemes da Silva, Antonio C B Nunes Filho, Vitor E E Rosa, Adriano Caixeta, Pedro A Lemos Neto, Henrique B Ribeiro, Breno O Almeida, José Mariani, Carlos M Campos, Alexandre A C Abizaid, José A Mangione, Roney O Sampaio, Paulo Caramori, Rogério Sarmento-Leite, Flávio Tarasoutchi, Marcelo Franken, Fábio S de Brito   +16 more
doaj   +1 more source

Improvement in Renal Function and Reduction in Serum Uric Acid with Intensive Statin Therapy in Older Patients: A Post Hoc Analysis of the SAGE Trial. [PDF]

, 2015
BackgroundImprovement in renal function and decreases in serum uric acid (SUA) have been reported following prolonged high-intensity statin (HMG-CoA reductase inhibitor) therapy.
Deedwania, Prakash C, Fayyad, Rana S, Laskey, Rachel E, Stone, Peter H, Wilson, Daniel J   +4 more
core  

Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean, Halliday, Christopher, Jahagirdar, Ravi, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Robson, Richard, Stotz, Stephanie C, Sweeney, Michael, Tsujikawa, Laura M, Wasiak, Sylwia, Wong, Norman C   +11 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source