Results 81 to 90 of about 987,918 (314)

Metabolic changes in summer active and anuric hibernating free-ranging brown bears (ursus arctos)

, 2013
The brown bear (Ursus arctos) hibernates for 5 to 6 months each winter and during this time ingests no food or water and remains anuric and inactive.
Abdul Rashid Qureshi, Johnson, Richard J,, Fröbert, Ole,, Peter Stenvinkel, Palm, Fredrik, Eriksson, Monica, Tobias Larsson, Zedrosser, Andreas, Josefsson, Johan, Johnson, Richard J., Anderstam, Björn, Friebe, Andrea,, Stenvinkel, Peter, Bankir, Lise, Johnson, Richard J, Sahdo, Berolla, Sahdo, Berolla,, Ann-Christin Bragfors-Helin, Andreas Zedrosser, Lise Bankir, Qureshi, Abdul Rashid,, Fröbert, Ole, Ole Fröbert, Björn Anderstam, Richard J Johnson, Anderstam, Björn,, Larsson, Tobias,, Friebe, Andrea, Berolla Sahdo, Bragfors-Helin, Ann-Christin,, Bragfors-Helin, Ann-Christin, Johnson, Richard J.,, Johan Josefsson, Josefsson, Johan,, Eriksson, Monica,, Qureshi, Abdul Rashid, Larsson, Tobias, Svensson, My, Stenvinkel, Peter,, Svensson, My,, My Svensson, Zedrosser, Andreas,, Palm, Fredrik,, Monica Eriksson, Bankir, Lise,, Fredrik Palm, Andrea Friebe   +46 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Renal Outcomes After Lung or Combined Heart‐Lung Transplantation in Pulmonary Hypertension

Pulmonary Circulation
Renal impairment is considered a contra‐indication for lung (LTX) or combined heart‐lung (HLTX) transplantation due to increased mortality. We hypothesized that renal impairment in pulmonary arterial hypertension (PAH) and chronic thromboembolic ...
Laura Hardy, Alexander D'Haenens, Ann Belmans, Rozenn Quarck, Gitte Aerts, Catharina Belge, Guido Claessen, Dirk Kuypers, Greet De Vlieger, Tom Verbelen, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Bart M. Vanaudenaerde, Geert Verleden, Lieven Dupont, Robin Vos, Marion Delcroix, Laurent Godinas   +17 more
doaj   +1 more source

Vitamin D and endothelial function in chronic kidney disease [PDF]

, 2014
PhDVitamin D deficiency in patients with chronic kidney disease, measured by reduced serum concentrations of 25 hydroxy vitamin D, is highly prevalent and associated with both endothelial dysfunction and an increased risk of cardiovascular disease ...
Dreyer, Gavin
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Natriumphosphat enthaltende Darmreinigungsmittel – eine Gefahr für die Niere? [PDF]

, 2009
There are several well-documented cases of acute irreversible renal failure involving renal calcium phosphate deposits after the use of bowel preparations containing sodium phosphate (e.g., Colophos®).
Bock, A, Kullak-Ublick, G A, Russmann, S., Kullack-Ubick, G., Russmann, S, Szeless, T, Szeless, Th, Bock, A.   +7 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The prevalence, clinical features, and long-term outcome of patients with primary Sjögren’s syndrome with renal involvement

Scientific Reports
This multicenter, retrospective longitudinal study identified primary Sjögren’s syndrome (pSS) patients with clinically significant renal involvement, and analyzed factors associated with predisposition.
Howook Jeon, Youngjae Park, Jennifer Jooha Lee, Yoo-Seok Suh, Seung-Ki Kwok, Sung-Hwan Park, Wan-Uk Kim, Jung Hee Koh   +7 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source