Results 81 to 90 of about 1,430,825 (310)

Renal Outcomes After Lung or Combined Heart‐Lung Transplantation in Pulmonary Hypertension

Pulmonary Circulation
Renal impairment is considered a contra‐indication for lung (LTX) or combined heart‐lung (HLTX) transplantation due to increased mortality. We hypothesized that renal impairment in pulmonary arterial hypertension (PAH) and chronic thromboembolic ...
Laura Hardy, Alexander D'Haenens, Ann Belmans, Rozenn Quarck, Gitte Aerts, Catharina Belge, Guido Claessen, Dirk Kuypers, Greet De Vlieger, Tom Verbelen, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Bart M. Vanaudenaerde, Geert Verleden, Lieven Dupont, Robin Vos, Marion Delcroix, Laurent Godinas   +17 more
doaj   +1 more source

A brief review of the literature on the malignant ureteral obstruction [PDF]

, 2018
Malignant ureteral obstruction (MUO) caused by a primarily urological tumor or secondary to a late-stage malignancy can be difficult for the urologist to manage. Due to a lack of clinical data on the management of MUO, every case is particular and should
Brînză, Adrian, Lupu, Sorin, Marcu, Dragos, Maxim, Laurian, Neagu, Tiberiu P, Peride, Ileana, Socea, Bogdan, Stanescu, Ana Maria Alexandra   +7 more
core   +1 more source

Preimplantation biopsy predicts delayed graft function, glomerular filtration rate and long-term graft survival of transplanted kidneys [PDF]

, 2016
Background The predictive value of preimplantation biopsies for long-term graft function is often limited by conflicting results. The aim of this study was to evaluate the influence of time-zero graft biopsy histological scores on early and late graft ...
Bianchi, Valentina, Citterio, Franco, FARAGGIANA DI SARZANA, Tullio, Favi, Evaldo, Giannakakis, Konstantinos, Pedroso, José A., Pietroni, Valentina, Romagnoli, Jacopo, Salerno, Maria P., Spagnoletti, Gionata, Toscano, Alessia   +10 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The prevalence, clinical features, and long-term outcome of patients with primary Sjögren’s syndrome with renal involvement

Scientific Reports
This multicenter, retrospective longitudinal study identified primary Sjögren’s syndrome (pSS) patients with clinically significant renal involvement, and analyzed factors associated with predisposition.
Howook Jeon, Youngjae Park, Jennifer Jooha Lee, Yoo-Seok Suh, Seung-Ki Kwok, Sung-Hwan Park, Wan-Uk Kim, Jung Hee Koh   +7 more
doaj   +1 more source

An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]

, 2012
Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Danish Ahmed, Manju Sharma, Pankaj S Yadav, Vikas Kumar   +3 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Pulmonary embolectomy in a patient with recent renal homotransplantation [PDF]

, 1964
A successful case of pulmonary embolectomy is described. Diagnosis was made when the patient developed cardiac arrest in the hospital ward. The embolus was removed with the aid of cardiopulmonary bypass.
Hermann, G, Marchioro, TL, Starzl, TE, Waddell, WR   +3 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source