Results 81 to 90 of about 12,320,426 (342)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Biomarkers of renal injury and function: diagnostic, prognostic and therapeutic implications in heart failure.

European Heart Journal, 2016
Heart failure guidelines suggest evaluating renal function as a routine work-up in every patient with heart failure. Specifically, it is advised to calculate glomerular filtration rate and determine blood urea nitrogen.
D. V. van Veldhuisen, L. Ruilope, A. Maisel, K. Damman   +3 more
semanticscholar   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Renal function in Ankylosing Spondylitis

Indian Journal of Rheumatology, 2017
Background: To study renal functions in patients with ankylosing spondylitis (AS) and compare with matched healthy controls and correlation between renal function parameters and disease activity markers.
Renu Saigal, Arun Kumar Agrawal, Laxmikant Goyal, Abhishek Agrawal, Naveen Gupta   +4 more
doaj   +1 more source

Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study [PDF]

, 2016
Judith van Dalem, Martijn C.G.J. Brouwers, Coen D.A. Stehouwer, André Krings, Hubert G. M. Leufkens, Johanna H. M. Driessen, Frank de Vries, Andrea M. Burden   +7 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

RENAL FUNCTION IN PEDIATRIC PATIENTS

Український Журнал Нефрології та Діалізу, 2017
The review provides basic information to evaluation of renal function in children. Consider the formula calculation of glomerular filtration rate based on creatinine, cystatin C, β2-microglobulin.
Yu. A. Morozov, T. V. Marchenko, I. I. Dementieva   +2 more
doaj   +1 more source

The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis [PDF]

, 2018
Qi Sun, Jiao Miao, Jing Luo, Qi Yuan, Hongdi Cao, Weifang Su, Yang Zhou, Lei Jiang, Li Fang, Chunsun Dai, Ke Zen, Junwei Yang   +11 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source