Results 41 to 50 of about 205,733 (287)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Demerits of using glycine 1.5% as irrigation fluid for transurethral resection of prostate in patients with severe renal insufficiency [PDF]

Journal of Krishna Institute of Medical Sciences University
Transurethral Resection of Prostate (TURP) syndrome is a rare but serious complication characterized by fluid absorption, leading to life-threatening complications. Although renal insufficiency is frequently associated with the patients posted for TURP,
Srinidhi Narayanan, Pranjali Kurhekar , Geetha Soundarya Udayakumar   +2 more
doaj  

Evaluation of oxidative stress biomarkers in patients with chronic renal failure: a case control study

BMC Research Notes, 2010
Background Oxidative stress is related to several diseases, including chronic renal insufficiency. The disequilibrium in the oxidant-antioxidant balance is the result of several metabolic changes.
Martinez-Vea Alberto, Mulero Miquel, Sánchez-Martos Vanesa, Marcas Luís, Nogues Rosa, Romeu Marta, Mallol Jordi, Giralt Montserrat   +7 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation analysis of preoperative renal insufficiency with major complications in patients who received a radical cystectomy and pelvic lymph node dissection: results of a retrospective observational analysis from a single center

Frontiers in Oncology
ObjectiveThe aim of this study was to explore the factors affecting the major complications and the impacts of preoperative renal function on the incidence of complications in radical cystectomy procedures.MethodsA retrospective review of 705 patients ...
Haixin Wang, Haixin Wang, Haixin Wang, Haixin Wang, Haiwen Huang, Han Hao, Han Hao, Han Hao, Zhijun Xi, Zhijun Xi, Zhijun Xi   +10 more
doaj   +1 more source

A rare and challenging renal transplant in a child with complex congenital defects - A case report

Indian Journal of Transplantation, 2021
Renal insufficiency is a distinct possibility in patients with congenital lower urinary tract abnormalities even though they are managed right from early childhood. Previously, such patients were not considered candidates for renal transplantation due to
Bharath N Kumar, Krishna V Baliga, Arjun Singh Sandhu   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Reversible Renal Insufficiency Secondary to Extrinsic Splenic Compression of the Kidney in a Patient with Chronic Lymphocytic Leukemia

The Scientific World Journal, 2010
While increased renal venous and direct renal parenchymal pressure may cause renal insufficiency, there are no prior reports of hypersplenism secondary to chronic lymphocytic leukemia (CLL) doing so.
Miriam Hadj-Moussa, James A. Brown
doaj   +1 more source

Association of high blood pressure with renal insufficiency: role of albuminuria, from NHANES, 1999-2006.

PLoS ONE, 2012
BackgroundThe relationship between hypertension and kidney disease is complicated. Clinical trials found intense blood pressure control was not associated with alterations in glomerular filtration rate (GFR) in all patients but did slow the rate of GFR ...
Ping Yan, Xiangzhu Zhu, Haiming Li, Martha J Shrubsole, Haiming Shi, Ming-zhi Zhang, Raymond C Harris, Chuan-Ming Hao, Qi Dai   +8 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source