Results 121 to 130 of about 1,621,854 (283)

Cholinergic Crisis Caused by Bethanechol and Glycerin Enema in a Patient with Diabetic Neuropathy: A Case Report

Journal of Hospital General Medicine
A cholinergic crisis is a condition characterized by nausea, vomiting, hypotension, bradycardia, diarrhea, diaphoresis,miosis, and salivation caused by acetylcholine receptor overstimulation.
Takashi Umeya, Shigeru Kumazaki, Katsutoshi Ando, Kenji Kurita, Shimpei Tominaga, Ryosuke Kametani   +5 more
doaj   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney disease

Frontiers in Endocrinology
ObjectiveTo investigate the potential crosstalk between TrkA, the high-affinity nerve growth factor receptor (NGFR), and cyclin-dependent kinase 5 (CDK5) in the pathogenesis of diabetic kidney disease (DKD).
Wenbo Xia, Mei Wang, Yongcai Gao, Yonghua Liu, Jing Li, Hongliang Zhang, Hongyan Luo, Dongyang Shen, Jing E, Bo Li, Yali Zheng   +10 more
doaj   +1 more source

Modulation of Brain Dead Induced Inflammation by Vagus Nerve Stimulation

, 2010
Because the vagus nerve is implicated in control of inflammation, we investigated if brain death (BD) causes impairment of the parasympathetic nervous system, thereby contributing to inflammation. BD was induced in rats.
Sticht, C., Schnuelle, P., Hoeger, S., Leuvenink, H., Ploeg, R., Leuvenink, H.; id_orcid, Birck, R., Beck, G., Fontana, J., van Son, W. J., Selhorst, J., Yard, B. A., Bergstraesser, C., Waldherr, R., Seelen, M. A.   +14 more
core   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Impact of hyperbaric oxygenation therapy (HBOT) on renal function in human

Scientific Reports
Hyperbaric Oxygenation Therapy (HBOT) is a widely used therapeutic option. It involves cycles with administration of 100% oxygen at increased atmospheric pressure to enhance oxygen delivery to tissues.
Solveig Kanowski, Yuanhao Shen, Till Klein, Marcus J. Moeller, Andreas Koch, Franziska Theilig   +5 more
doaj   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Functional significance of the pattern of renal sympathetic nerve activation

, 1999
To assess the renal functional significance of the pattern of renal sympathetic nerve activation, computer-generated stimulus patterns (delivered at constant integrated voltage) were applied to the decentralized renal sympathetic nerve bundle and renal ...
Gerald F. Dibona, Linda L. Sawin
core   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source