Results 131 to 140 of about 1,621,854 (283)

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Vagal afferent activity and renal nerve release of dopamine

, 1985
To investigate the involvement of vagal afferents in renal nerve release of catecholamines, we compared norepinephrine, dopamine, and epinephrine excretion from innervated and chronically denervated kidneys in the same rat.
N. Morgunov, A. D. Baines
core   +1 more source

Treatment‐Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Graphical Abstract Objective This study aimed to characterize whole blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or B lymphocyte stimulator/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to nonresponse. Methods Whole blood RNA sequencing was performed
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C. Jury, Coziana Ciurtin   +9 more
wiley   +1 more source

Baroreceptor effects on renal and adrenal nerve activity

, 1976
Spontaneous efferent discharges were recorded from nerve filaments dissected from adrenal and renal nerve bundles in the rabbit. Raising of the systemic blood pressure or stimulation of the depressor nerve caused a decrease in discharge rate in these ...
A Nijima
core   +1 more source

Learning beyond the lab: A gamified approach to anatomy education in a museum‐based experience

Anatomical Sciences Education, EarlyView.
Abstract Anatomy education, traditionally rooted in descriptive instruction and cadaveric dissection, is undergoing a significant transformation through the integration of educational technologies and contemporary pedagogical strategies. Among these, active learning methodologies, such as gamified‐based learning, have emerged as approaches designed to ...
Wendell Nunes da Silva, Diego Pulzatto Cury, Silvia Lacchini, Ana Paula Cremasco Takano   +3 more
wiley   +1 more source

Renal function and renal afferent and efferent nerve activity

, 1982
Recent microperfusion studies have fully substantiated the direct action of catecholamines on renal tubular reabsorptive rates. Surprisingly, these techniques have not provided consistent information on the nature of the adrenoceptor responsible for the
N. G. Moss
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Efficacy and safety of sympathetic mapping and ablation of renal nerves for the treatment of hypertension (SMART): 6-month follow-up of a randomised, controlled trialResearch in context

EClinicalMedicine
Summary: Background: Previous trials of renal denervation (RDN) have been designed to investigate reduction of blood pressure (BP) as the primary efficacy endpoint using non-selective RDN without intraoperatively verified RDN success.
Jie Wang, Yuehui Yin, Chengzhi Lu, Zhibing Lu, Jialu Hu, Yue Wang, Junbo Ge, Hong Jiang, Chen Yao, Xiaoyan Yan, Wei Ma, Xiaoyong Qi, Yi Dang, Shaoliang Chen, Jiancheng Zhu, Dongmei Wang, Chao Ding, Weimin Wang, Jian Liu, Yanbin Wang, Hui Li, Zhenhua Pan, Kaijun Cui, Chengzong Li, Xinjian Liang, Weijie Chen, Paul A. Sobotka, JingJing Zhang, Murray Esler, Ningling Sun, Minglong Chen, Yong Huo   +31 more
doaj   +1 more source

A microTMS system for peripheral nerve stimulation

, 2019
Transcranial magnetic stimulation (TMS) is a well-established non-invasive technique for the treatment of several neurological disorders. TMS can also be used to stimulate elements of the peripheral nervous system, such as the median and the ulnar nerves.
G. Bonmassar, S. Rutkove, M. Colella, R. Laher, A. Pascual-Leone, D. Press, M. Liberti, C. McIlduff   +7 more
core   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source