Results 41 to 50 of about 1,621,854 (283)

Role of Renal Nerves in the Stimulation of the Renin System by Reduced Renal Arterial Pressure [PDF]

Hypertension, 1999
Abstract —The aim of this study was to determine the role of renal innervation in the prolonged stimulation of renin secretion and renin synthesis accompanying renal artery stenosis. Male Sprague-Dawley rats, in which the left kidney had been denervated or sham denervated 4 days earlier, received a left renal artery clip (ID 0 ...
C, Wagner, M, Hinder, B K, Krämer, A, Kurtz   +3 more
openaire   +2 more sources

Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study

Scientific Reports, 2023
Catheter-based approaches may have inherent limitations in achieving effective renal denervation (RDN) and treatment of atrial fibrillation (AF). This study aimed to investigate the acute effects of novel laparoscopic RDN on modulating AF inducibility ...
Soonil Kwon, Eue-Keun Choi, Hyo-Jeong Ahn, So-Ryoung Lee, Seil Oh, Si Hyun Kim, Minh-Tung Do, Jang Hee Han, Chang Wook Jeong   +8 more
doaj   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat

Frontiers in Physiology, 2021
Excessive sympathetic activation plays crucial roles in the pathogenesis of hypertension. Chemical stimulation of renal afferents increases the sympathetic activity and blood pressure in normal rats.
Chao Ye, Fen Zheng, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu, Guo-Qing Zhu   +8 more
doaj   +1 more source

Calcitonin gene-related peptide is a stimulator of renin secretion [PDF]

, 1988
Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [
Fischer, J. A., R Muff, Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., A Kurtz, M P Gnädinger, W Born, Muff, R., J M Lundberg, T Hökfelt, P Weidmann, Kurtz, Armin, Lundberg, J. M., D E Uehlinger, Born, W., Millberg, B. I., Hökfelt, T., J A Fischer, B I Millberg, Weidmann P, Fischer JA, Millberg BI, Born W, Hökfelt T, Kurtz A, Uehlinger DE, Gnädinger MP, Lundberg JM, Muff R   +29 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Atrial fibrillation and autonomic nervous system: A translational approach to guide therapeutic goals

Journal of Arrhythmia, 2021
The autonomic nervous system (ANS) is known to play an important role in the genesis and maintenance of atrial fibrillation (AF). Biomolecular and genetic mechanisms, anatomical knowledges with recent diagnostic techniques acquisitions, both invasive and
Marco Rebecchi, Germana Panattoni, Bressi Edoardo, Ermenegildo deRuvo, Luigi Sciarra, Alessandro Politano, Marianna Sgueglia, Chiara Ricagni, Sara Verbena, Cinzia Crescenzi, Catia Sangiorgi, Alessio Borrelli, Lucia De Luca, Antonio Scarà, Domenico Grieco, Ilaria Jacomelli, Annamaria Martino, Leonardo Calò   +17 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Low-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment

Frontiers in Pharmacology
BackgroundNeurostimulation is an emerging treatment for conditions like hypertension. The renal nerves, comprising sensory afferent and sympathetic efferent fibers, are crucial for blood pressure (BP) regulation.
Ibrahim M. Salman, Omar Z. Ameer, Sarah F. Hassan, Arun Sridhar, Yee-Hsee Hsieh, Stephen J. Lewis, Stephen J. Lewis   +6 more
doaj   +1 more source