Results 31 to 40 of about 171,022 (301)

Factors predicting post-dialysis fatigue of maintenance hemodialysis patients

open access: yesRenal Replacement Therapy, 2023
Aims Post-dialysis fatigue is a common complication in maintenance hemodialysis patients. This study aims to evaluate post-dialysis fatigue and discover related risk factors. Design and methods In this cross-sectional study, we used the specific scale to
Huiwen Li   +3 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Phytotherapy and treatment of cystitis: current trends

open access: yesPočki, 2019
The treatment of lower urinary tract infections, in particular cystitis, remains an urgent problem of modern medicine. The high prevalence of the disease, formation of resistant strains of cau­sative microorganisms, a change in microbiota, and a limited ...
D.D. Ivanov
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

SPossibilities of 4-Component Therapy in Renal Protection: UNIKUM Trial Results

open access: yesPočki, 2012
There are given the results of first in Ukraine experience of 4-component therapy (angiotensin II receptor blockers, β-blocker, acetylsalicylic acid, statin) — multimodal strategy under randomized study in patients with chronic renal disease.
D.D. Ivanov
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Use orotic acid in the treatment of pathological conditions associated with hyperuricemia

open access: yesPočki, 2014
Hyperuricemia - a condition characterized by elevated relative to normal ranges, levels of uric acid in the blood. Among the diseases caused by hyperuricemia, most noteworthy are gout, urate nephropathy, and urolithiasis.
D.D. Ivanov, Ya.A. Dombrovskyi
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Nifuratel Application in Therapy of Urinary Tract Infections

open access: yesPočki, 2014
The article examines the treatment of urinary tract infections, in particular attention was paid to antibiotic therapy. It is emphasized that the results of many studies and practical experience enable to consider group of nitrofurans, including ...
Ya.A. Dombrovskyi, D.D. Ivanov
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

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