Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Continuous renal replacement therapy [PDF]
, 2012 Acute renal failure refers to sudden deterioration in biochemical and physiological functioning of kidneys and often associated with multi organ failure.
Amlani, Gulzar Salman
core +1 more source
Continued monitoring of acute kidney injury survivors might not be necessary in those regaining an estimated glomerular filtration rate > 60 mL/min at 1 year [PDF]
, 2017 Background. Severe acute kidney injury (AKI) among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who recover to normal renal function.
Geddes, Colin C. +4 more
core +1 more source
SPossibilities of 4-Component Therapy in Renal Protection: UNIKUM Trial Results
Počki, 2012 There are given the results of first in Ukraine experience of 4-component therapy (angiotensin II receptor blockers, β-blocker, acetylsalicylic acid, statin) — multimodal strategy under randomized study in patients with chronic renal disease.
D.D. Ivanov
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The effect of very low-calorie diets on renal and hepatic outcomes : a systematic review [PDF]
, 2013 Peer reviewedPublisher ...
Broom, J +3 more
core +3 more sources
Use orotic acid in the treatment of pathological conditions associated with hyperuricemia
Počki, 2014 Hyperuricemia - a condition characterized by elevated relative to normal ranges, levels of uric acid in the blood. Among the diseases caused by hyperuricemia, most noteworthy are gout, urate nephropathy, and urolithiasis.
D.D. Ivanov, Ya.A. Dombrovskyi
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Nifuratel Application in Therapy of Urinary Tract Infections
Počki, 2014 The article examines the treatment of urinary tract infections, in particular attention was paid to antibiotic therapy. It is emphasized that the results of many studies and practical experience enable to consider group of nitrofurans, including ...
Ya.A. Dombrovskyi, D.D. Ivanov
doaj +1 more source