Results 51 to 60 of about 3,286,893 (204)

Randomised controlled trial of an interactive multimedia decision aid on hormone replacement therapy in primary care [PDF]

, 2001
Objective To determine whether a decision aid on hormone replacement therapy influences decision making and health outcomes.Design Randomised controlled trial.Setting 26 general practices in the United Kingdom.Participants 205 women considering hormone ...
Davis, H, Haines, A, Coulter, A, Gray, A, Murray, E, Tai, SS   +5 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Demographics of blood pressure and hypertension in children on renal replacement therapy in Europe [PDF]

, 2011
Hypertension is a well-known complication in children on renal replacement therapy and an important risk factor for cardiovascular disease in later life.
van Stralen, Karlijn J, Groothoff, Jaap W, Jager, Kitty J., Lewis, Malcolm A., Jaap W. Groothoff, Simonetti, Giacomo D, Schaefer, Franz, Kramer, A Marijn, Novljan, Gregor, van Stralen, Karlijn J., Groothoff, Jaap W., Kitty J. Jager, Tomáš Seeman, Simonetti, Giacomo D., Enrico Verrina, Franz Schaefer, Karlijn J. van Stralen, Michael Boehm, Malcolm A. Lewis, Kramer, A. Marijn, Lewis, Malcolm A, Boehm, Michael, A. Marijn Kramer, Giacomo D. Simonetti, Seeman, Tomáš, Jager, Kitty J, Verrina, Enrico, Gregor Novljan   +27 more
core   +1 more source

Comparison of siRNA-mediated silencing of glycosaminoglycan synthesis genes and enzyme replacement therapy for mucopolysaccharidosis in cell culture studies [PDF]

, 2012
Cytotoxicity of laronidase (Aldurazyme®), employed in enzyme replacement therapy (ERT) for mucopolysaccharidosis type I (MPS I) and various siRNAs, tested previously in studies on substrate reduction therapy (SRT) for mucopolysaccharidoses, was ...
Banecka-Majkutewicz, Zyta, Węgrzyn, Alicja, Gabig-Cimińska, Magdalena, Jakóbkiewicz-Banecka, Joanna, Chmielarz, Izabela, Malinowska, Marcelina   +5 more
core   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Determinants of difficulty in activities of daily living in ambulatory patients undergoing hemodialysis

Renal Replacement Therapy, 2018
Background Patients undergoing hemodialysis (HD) have difficulty performing activities of daily living (ADL) compared to healthy people. ADL difficulty is an early predictor of loss of independence and mortality in older community-living people. However,
Takaaki Watanabe, Toshiki Kutsuna, Kei Yoneki, Manae Harada, Takahiro Shimoda, Yusuke Matsunaga, Norio Murayama, Ryota Matsuzawa, Yasuo Takeuchi, Atsushi Yoshida, Atsuhiko Matsunaga   +10 more
doaj   +1 more source

No Added Mortality Benefit From Current Approaches to Renal Replacement Therapy in ICU Patients [PDF]

, 2014
Hospital-acquired acute kidney injury (AKI), a common and harmful renal disorder, is an independent risk factor for short-term and long-term mortality particularly in critically ill patients.
Helmut Schiffl
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Absence of complement terminal pathway activity in C6-deficient mice prolongs survival in a mouse model of severe malarial infection

Immunobiology
Background: Malaria is an important and serious parasite-induced disease associated with severe anemia and multiple organ failure (MOF) that can be lethal in humans.
Tomoaki Kamiya, Yuki Miyasaka, Hangsoo Kim, Sosuke Fukui, Masatoshi Inoue, Masatoshi Ishigami, Yasuhiro Suzuki, Shoichi Maruyama, Tamio Ohno, Timothy R. Hughes, B. Paul Morgan, Masashi Mizuno   +11 more
doaj   +1 more source

Hormone replacement therapy: perspectives from women, medicine and sociology [PDF]

, 1997
Developed on the boundary between medicine and sociology, this thesis develops a critique of the perspectives of these disciplines through analysis of a study of women's perspectives on hormone replacement therapy.
Griffiths, Frances Ellen, Griffiths, F.E.   +1 more
core