Results 31 to 40 of about 172,502 (268)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Renal replacement therapy in Iran.

Urology journal, 2007
Corresponding Author: Mitra Mahdavi-Mazdeh, MD Management Center for Transplantation and Special Diseases, Vanak Sq, Tehran, Iran Tel: +98 21 8864 4515 Fax: +98 21 8864 4516 E-mail: mmahdavi@tums.ac.ir Dialysis and kidney transplantation are the only treatment options available for patients suffering from end-stage renal disease (ESRD).
Mahdavi-Mazdeh, Mitra, Heidary Rouchi, Alireza, Norouzi, Shahram, Aghighi, Mohammad, Rajolani, Hamid, Ahrabi, Sadegh   +5 more
openaire   +3 more sources

Etiology of Renal Replacement Therapy in Iran [PDF]

International Journal of Nephrology, 2019
Introduction. End-stage renal disease (ESRD) is one of the most common life-threatening diseases. In the past two decades, several factors were held responsible as the cause of this condition. The present study aimed to determine the causes of ESRD in the province of Khorasan Razavi, Iran. Materials and Methods. This cross-sectional study was conducted
Negar Morovatdar, Gholamreza Tayebi Nasrabad, Konstantinos Tsarouhas, Ramin Rezaee   +3 more
openaire   +4 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Absence of complement terminal pathway activity in C6-deficient mice prolongs survival in a mouse model of severe malarial infection

Immunobiology
Background: Malaria is an important and serious parasite-induced disease associated with severe anemia and multiple organ failure (MOF) that can be lethal in humans.
Tomoaki Kamiya, Yuki Miyasaka, Hangsoo Kim, Sosuke Fukui, Masatoshi Inoue, Masatoshi Ishigami, Yasuhiro Suzuki, Shoichi Maruyama, Tamio Ohno, Timothy R. Hughes, B. Paul Morgan, Masashi Mizuno   +11 more
doaj   +1 more source

Determinants of difficulty in activities of daily living in ambulatory patients undergoing hemodialysis

Renal Replacement Therapy, 2018
Background Patients undergoing hemodialysis (HD) have difficulty performing activities of daily living (ADL) compared to healthy people. ADL difficulty is an early predictor of loss of independence and mortality in older community-living people. However,
Takaaki Watanabe, Toshiki Kutsuna, Kei Yoneki, Manae Harada, Takahiro Shimoda, Yusuke Matsunaga, Norio Murayama, Ryota Matsuzawa, Yasuo Takeuchi, Atsushi Yoshida, Atsuhiko Matsunaga   +10 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Effectiveness of additional topical antibiotics for recurrent or refractory exit-site infection: a case series

Renal Replacement Therapy
Background Japanese peritoneal dialysis (PD) guidelines do not suggest applying mupirocin/gentamicin ointment to the exit sites of PD patients to prevent exit-site infection (ESI).
Nao Asai, Yasuhiro Suzuki, Akimasa Asai, Hiroshi Kinashi, Keisuke Kamiya, Junichiro Hagita, Naoya Matsuoka, Suzuka Kawamura, Sosuke Fukui, Hangsoo Kim, Makoto Yamaguchi, Takayuki Katsuno, Masashi Mizuno, Takuji Ishimoto, Yasuhiko Ito   +14 more
doaj   +1 more source