Results 51 to 60 of about 3,813 (255)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The predictive value of renal vascular resistance index and serum biomarkers for sepsis-associated acute kidney injury: a retrospective study

BMC Nephrology
Background Sepsis-associated acute kidney injury (AKI) presents a significant clinical challenge, necessitating the identification of predictive indicators for early detection and intervention.
Daofeng Huang, Zhaobin Yang, Luzhen Qiu, Jinzhan Lin, Xiaomei Cheng   +4 more
doaj   +1 more source

Correlation of Albuminuria and Renal Doppler Indices with Myocardial Function in Patients with Nephrotic Syndrome

SVU - International Journal of Medical Sciences
Background: Nephrotic syndrome (NS) is characterized by proteinuria and edema, often stemming from minimal change disease. Secondary causes include systemic conditions and medications.
AbdelKader A. Hashim, Ghada M. Abdelrazek , ِAreej Alkhateeb, Aml Ahmed Shohdy , Ahmed G. Bakry   +4 more
doaj   +1 more source

Scintigraphy and Doppler ultrasonography for the evaluation of obstructive urinary calculi

Brazilian Journal of Medical and Biological Research, 2001
Forty-seven patients with unilateral obstructive calculi (12 males and 35 females) were submitted to 99mTc-diethylene triamine pentaacetic acid (DTPA) or 99mTc-dimercaptosuccinic acid (DMSA) scans for assessment of renal function.
L. Gandolpho, M. Sevillano, A. Barbieri, S. Ajzen, N. Schor, V. Ortiz, I.P. Heilberg   +6 more
doaj   +1 more source

Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11‐Year‐Old Children Born Preterm or At Term

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Prematurity disrupts the perinatal maturation of the microvasculature and macrovasculature and confers high risk of vascular dysfunction later in life.
Fang‐Fei Wei, Anke Raaijmakers, Jesus D. Melgarejo, Nicholas Cauwenberghs, Lutgarde Thijs, Zhen‐Yu Zhang, Cai‐Guo Yu, Elena Levtchenko, Harry A. J. Struijker‐Boudier, Wen‐Yi Yang, Tatiana Kuznetsova, Sean Kennedy, Peter Verhamme, Karel Allegaert, Jan A. Staessen   +14 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Extracorporeal shock wave lithotripsy effect on renal arterial resistive index changing [PDF]

Medicinski Glasnik, 2019
Aim To investigate a correlation between resistive index (RI) level changes following extracorporeal shock wave lithotripsy (ESWL) in treated and non-treated kidneys depending on the ESWL treatment intensity.
Emir Milišić, Zlatan Zvizdić, Asmir Jonuzi, Mustafa Hiroš, Lejla Milišić, Amira Mešić, Edin Begić   +6 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Role of Renal Resistive Index in early detection of Diabetic Nephropathy in Type II Diabetic Patients

SVU - International Journal of Medical Sciences
Background: Diabetic nephropathy (DN) burdens health services; renal resistive index (RI) indicates atherosclerotic changes. Objectives: Assessing renal artery RI for early detection of DN in type II diabetes (T2DM) patients.
Nihal O.Youssif Ali Ali , Ahmed M. Khalaf-Awad , Fayed HM , Abd elkader Ahmed Hashim, Ghada M. Abd ElRazik   +4 more
doaj   +1 more source