Results 51 to 60 of about 6,033 (178)

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Renal Denervation – a Modern Option for Treating Resistant Hypertension

Journal of Interdisciplinary Medicine, 2020
Hypertension is one of the main cardiovascular risk factors, and it remains an important health problem, demonstrating an increasing incidence despite new treatment methods.
Rodean Ioana, Chibelean Călin
doaj   +1 more source

Percutaneous Sympathetic Renal Denervation

Revista Brasileira de Cardiologia Invasiva (English Edition), 2013
ABSTRACTArterial hypertension is a highly prevalent disease and is associated with increased cardiovascular risk. Despite great advances in drug therapy, a considerable number of patients do not have an effective control of the disease, despite the use of multiple drugs, usually in high doses.
de Melo Bernardi, Fernando Luiz, Gomes, Wilton Francisco, Spadaro, André Gasparini, Filho, Antônio Esteves, Bortolotto, Luiz Aparecido, Scanavacca, Maurício Ibrahim, Lemos, Pedro Alves   +6 more
openaire   +1 more source

Application in Hypertension of Renal Sympathetic Denervation – A Review [PDF]

Interventional Cardiology Review, 2013
Afferent and efferent sympathetic nerves of the kidney located in the adventitia of the renal artery are involved in the regulation of blood pressure and play a pathophysiological role in the progression and maintenance of hypertension. Renal sympathetic denervation is a potent and safe catheter-based therapeutic approach for the treatment of patients ...
Dominik, Linz, Felix, Mahfoud, Sebastian, Ewen, Stephan H, Schirmer, Jan, Reil, Christian, Ukena, Michael, Böhm   +6 more
openaire   +2 more sources

Acute Intermittent Porphyria Triggered by COVID‐19 Mimicking Guillain–Barré Syndrome: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Acute intermittent porphyria (AIP) is a rare heme biosynthesis disorder in which the accumulation of neurotoxic porphyrin precursors precipitates neurovisceral attacks. Intercurrent infections, including coronavirus disease 2019 (COVID‐19), may trigger or exacerbate AIP and complicate diagnosis, as clinical manifestations can resemble those of
Payman Sadeghi, Masood Ghahvechi Akbari, Seyed Abbas Hassani, Hosein Alimadadi, Morteza Heidari, Vahid Ziaee   +5 more
wiley   +1 more source

Blood Pressure Response to Main Renal Artery and Combined Main Renal Artery Plus Branch Renal Denervation in Patients With Resistant Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSingle‐electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)‐lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure.
Karl Fengler, Sebastian Ewen, Robert Höllriegel, Karl‐Philipp Rommel, Saaraaken Kulenthiran, Lucas Lauder, Bodo Cremers, Gerhard Schuler, Axel Linke, Michael Böhm, Felix Mahfoud, Philipp Lurz   +11 more
doaj   +1 more source

Renal Artery Stenosis After Renal Sympathetic Denervation

Journal of the American College of Cardiology, 2012
To the Editor: Renal sympathetic denervation (RDN) has been adopted in a number of countries as an additional treatment option to supplement antihypertensive therapy in patients with resistant hypertension. Concerns have been raised with regard to the possible occurrence of renal artery stenosis (
Kaltenbach, Benjamin, Id, Dani, Franke, Jennifer C., Sievert, Horst, Hennersdorf, Marcus, Maier, Jens, Bertog, Stefan C.   +6 more
openaire   +2 more sources

Distinct Neuronal Activation in the Paraventricular Nucleus of the Hypothalamus Accompanies Baroreflex Impairment and Elevated Cardiac Sympathetic Tone in Salt‐Loaded Rats

European Journal of Neuroscience, Volume 63, Issue 10, May 2026.
This study investigated an animal model of short‐term high‐salt exposure (2% NaCl) for 7 days and its effects on baroreflex function, cardiac autonomic balance, and the pattern of paraventricular nucleus of the hypothalamus (PVH) neuronal activation during a baroreflex loading. High salt intake leads to an increase in blood pressure (BP) and heart rate
Angelo Bernak de Oliveira, Pedro Sousa Soares, Paula Magalhães Gomes, Vagner Roberto Antunes   +3 more
wiley   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, Volume 13, Issue 20, 9 April 2026.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis

BMC Cardiovascular Disorders, 2023
Background Renal denervation (RDN) has emerged in recent years as a possible treatment for hypertension. The first sham-controlled trial showed a small magnitude and non-significant in the blood pressure (BP) lowering effect, also due to a substantial ...
Adriana Fernandes, Cláudio David, Fausto J Pinto, João Costa, Joaquim J Ferreira, Daniel Caldeira   +5 more
doaj   +1 more source