Results 71 to 80 of about 918,306 (202)

The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models

International Journal of Hypertension, 2021
Background. Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients.
Demin Liu, Jing Wang, Haijuan Hu, Guoqiang Gu, Rui Ding, Ruiqin Xie, Wei Cui   +6 more
doaj   +1 more source

Device-Based Treatment in Hypertension: At the Forefront of Renal Denervation

Cardiology Discovery, 2021
. Percutaneous renal denervation is a novel device therapy that modifies the circulatory regulatory system and has received considerable attention recently.
Kazuomi Kario, Douglas A. Hettrick, Murray D. Esler, Xiaoxia Fu, Tianyu Xu.   +4 more
doaj   +1 more source

Beyond the Heart‐Lung Axis: A Review of the Crosstalk Between the Hemodynamic, Neurohormonal, and Immune Systems in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Pulmonary hypertension is driven by dynamic crosstalk beyond the physical connection between the heart and lung, involving neurohormonal systems, immune pathways, and peripheral organs. This review highlights how multisystem signaling contributes to disease progression and may reveal new diagnostic and therapeutic targets.
Alejandro A. Vega, Juliet M. Alfaro, David S. Pinto, Maryam Emamimeybodi, Soban Umar   +4 more
wiley   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Percutaneous Sympathetic Renal Denervation

Revista Brasileira de Cardiologia Invasiva (English Edition), 2013
ABSTRACTArterial hypertension is a highly prevalent disease and is associated with increased cardiovascular risk. Despite great advances in drug therapy, a considerable number of patients do not have an effective control of the disease, despite the use of multiple drugs, usually in high doses.
de Melo Bernardi, Fernando Luiz, Gomes, Wilton Francisco, Spadaro, André Gasparini, Filho, Antônio Esteves, Bortolotto, Luiz Aparecido, Scanavacca, Maurício Ibrahim, Lemos, Pedro Alves   +6 more
openaire   +1 more source

Effects of Renal Denervation on Sympathetic Activation, Blood Pressure and Glucose Metabolism in Patients with Resistant Hypertension

Frontiers in Physiology, 2012
Increased central sympathetic drive is a hallmark of a number of important and common clinical conditions including essential hypertension, insulin resistance, heart failure, and chronic kidney disease.
Markus Peter Schlaich, Dagmara eHering, Paul A Sobotka, Henry eKrum, Gavin W Lambert, Elisabeth A Lambert, Murray D Esler   +6 more
doaj   +1 more source

Renal ¹²³I-MIBG Uptake before and after Live-Donor Kidney Transplantation

Diagnostics, 2020
Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123
Thomas Rasmussen, Robin de Nijs, Lene Kjær Olsen, Anne-Lise Kamper, Lia Evi Bang, Marie Frimodt-Møller, Henning Kelbæk, Søren Schwartz Sørensen, Andreas Kjær, Bo Feldt-Rasmussen, Jesper Hastrup Svendsen, Philip Hasbak   +11 more
doaj   +1 more source

Shear Stress‐Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
The vasculo‐splenic axis during exercise: shear stress triggers the release of medium/large extracellular vesicles from vascular endothelial cells via activation of Piezo1, shuttling Piezo1 to the smooth muscle cells in the splenic capsule; the translocated Piezo1 within the splenic capsule acts as a downstream effector of the α1‐adrenergic receptor ...
Jing Lou, Mingzong Yang, Yang Hu, Xuyun Liu, Han Li, Zihang Feng, Yuxin Xi, Changyang Xing, Lijun Yuan, Jia Li, Shengpeng Wang, Feng Gao, Xing Zhang   +12 more
wiley   +1 more source

Renal Artery Stenosis After Renal Sympathetic Denervation

Journal of the American College of Cardiology, 2012
To the Editor: Renal sympathetic denervation (RDN) has been adopted in a number of countries as an additional treatment option to supplement antihypertensive therapy in patients with resistant hypertension. Concerns have been raised with regard to the possible occurrence of renal artery stenosis (
Kaltenbach, Benjamin, Id, Dani, Franke, Jennifer C., Sievert, Horst, Hennersdorf, Marcus, Maier, Jens, Bertog, Stefan C.   +6 more
openaire   +2 more sources

Application in Hypertension of Renal Sympathetic Denervation – A Review [PDF]

Interventional Cardiology Review, 2013
Afferent and efferent sympathetic nerves of the kidney located in the adventitia of the renal artery are involved in the regulation of blood pressure and play a pathophysiological role in the progression and maintenance of hypertension. Renal sympathetic denervation is a potent and safe catheter-based therapeutic approach for the treatment of patients ...
Dominik, Linz, Felix, Mahfoud, Sebastian, Ewen, Stephan H, Schirmer, Jan, Reil, Christian, Ukena, Michael, Böhm   +6 more
openaire   +2 more sources