Results 61 to 70 of about 918,306 (202)

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Acute intermittent carotid body stimulations induce long‐term facilitation of respiratory–cardiovascular coupling in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Carotid body (CB) overactivity is implicated in sympathetic excitation and development of hypertension, but its direct role in initiating respiratory–cardiovascular dysfunction remains unclear. Here, we used the in situ working heart–brainstem preparation in rats, an anaesthesia‐free model, to test the effects of acute CB ...
Ambre A. Linossier, Christian Gestreau, Clément Menuet   +2 more
wiley   +1 more source

A Clinician’s Perspective of Renal Sympathetic Nerve Contribution to Hypertension

Frontiers in Physiology, 2015
The renal sympathetic nerves have a significant contribution to the control of different aspects of kidney function and blood pressure. Early animal studies of renal denervation (RDN) in a large number of different models of hypertension showed that RDN ...
Alexandros eBriasoulis, George Louis Bakris   +1 more
doaj   +1 more source

Adaptations of glucagon‐like peptide‐1 receptor agonist‐induced weight loss, drivers of weight regain and future directions of therapeutics

The Journal of Physiology, EarlyView.
Abstract figure legend During GLP‐1RA treatment reduced appetite and energy intake, delayed gastric emptying, decreased visceral fat mass and improved glycaemic control contribute to weight loss. After treatment cessation these benefits are partially or completely reversed, resulting in weight regain, accompanied by increased appetite and energy intake,
Camille E. M. Piguet, Rosie Nucci, Jacqueline L. Beaudry   +2 more
wiley   +1 more source

Renal Sympathetic Denervation for Treating Resistant Hypertension

Circulation Journal, 2013
Systemic hypertension represents a significant global concern, because it contributes to vascular and renal morbidity, cardiovascular mortality, and economic burden, hence the impact of hypertension is a major issue in public health worldwide. Improving high blood pressure management is therefore fundamental to influencing clinical outcomes.
Polimeni, A., Curcio, A., Indolf, C.
openaire   +4 more sources

Persistent Increase in Blood Pressure After Renal Nerve Stimulation in Accessory Renal Arteries After Sympathetic Renal Denervation.

, 2016
Blood pressure response to renal denervation is highly variable, and the proportion of responders is disappointing. This may be partly because of accessory renal arteries too small for denervation, causing incomplete ablation.
van Hasselt, Boudewijn A. A. M., Delnoy, Peter Paul H. M., Le Polain De Waroux, Jean-Benoît, Misier, Anand R. Ramdat, Smit, Jaap Jan J., Staessen, Jan A., Lau, Elizabeth O Y, Delnoy, Peter Paul H M, Hoogerwaard, Annemiek F., de Waroux, Jean-Benoit le Polain, Smit, Jaap Jan J, de Jong, Mark R., van Hasselt, Boudewijn A A M, Lau, Elizabeth O.Y., Hoogerwaard, Annemiek F, Delnoy, Peter Paul H.M., Ramdat Misier, Anand R., van Hasselt, Boudewijn A.AM., Lau, Elizabeth O. Y., de Jong, Mark R, Adiyaman, Ahmet, Persu, Alexandre, Staessen, Jan A, Ramdat Misier, Anand R, Gal, Pim, Heeg, Jan-Evert, Elvan, Arif   +26 more
core   +1 more source

Cardiovascular Autonomic Neuropathy in Charcot–Marie–Tooth Disease: A Genotype‐Stratified Study of PMP22 Duplication and GJB1 Mutation Carriers

Journal of the Peripheral Nervous System, Volume 31, Issue 4, December 2026.
ABSTRACT Background and Aims Data on cardiovascular autonomic neuropathy (CAN) are sparse in Charcot–Marie–Tooth disease. We aimed to determine the prevalence of CAN in CMT1A and CMTX1 and its associations with neuropathy severity and heart rate variability (HRV), compared with age‐ and sex‐matched controls. Methods Thirty‐six CMT1A, 24 CMTX1 patients,
Kryštof Prášil, Veronika Potočková, Tomáš Nedělka, Alžběta Prášilová, Radim Mazanec   +4 more
wiley   +1 more source

Renal nerve stimulation: complete versus incomplete renal sympathetic denervation

, 2021
Purpose Blood pressure (BP) reduction after renal sympathetic denervation (RDN) is highly variable. Renal nerve stimulation (RNS) can localize sympathetic nerves.
Mark R. de Jong, Annemiek F. Hoogerwaard, Jaap-Jan J. Smit, Ahmet Adiyaman, Jan-Evert Heeg, Arif Elvan, Boudewijn A. A. M. van Hasselt   +6 more
core   +1 more source

Renal Denervation by Noninvasive Stereotactic Radiotherapy Induces Persistent Reduction of Sympathetic Activity in a Hypertensive Swine Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We have previously reported the feasibility of noninvasive stereotactic body radiotherapy (SBRT) as a novel approach for renal denervation. Methods and Results Herein, from a translational point of view, we assessed the antihypertensive effect
Xingxing Cai, Yichen Shen, Yuli Yang, Wei Wang, Li Qian, Jing Cai, Runmin Chi, Shunxuan Yu, Keke Li, Zhixing Wei, Taizhong Chen, Yudong Fei, Yaqin Han, Xiu Chen, Ming Liu, Yifei Liu, Dengbin Wang, Mawei Jiang, Yi‐Gang Li   +18 more
doaj   +1 more source

Baroreflex Activation Therapy in Patients With Resistant Hypertension: A Single‐Center Real‐World Analysis of Blood Pressure Response and Procedural Safety

The Journal of Clinical Hypertension, Volume 28, Issue 11, November 2026.
ABSTRACT Baroreflex activation therapy (BAT) has emerged as a treatment option for patients with resistant hypertension; however, real‐world data on blood pressure response and procedural safety of the second‐generation Barostim Neo system remain limited.
Shaima Al‐asbahi, Olaf Oldenburg, Henrik Fox   +2 more
wiley   +1 more source