Results 41 to 50 of about 89,917 (257)
Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
Advanced Science, EarlyView.ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang +5 more
wiley +1 more source
Single‐Sensor Vibration Sensing in Anisotropic Composites Enabled by Disordered Metasurfaces
Advanced Science, EarlyView.This work develops a single‐sensor vibration sensing (SSVS) framework that integrates disordered metasurfaces with compressive sensing. Comprehensive numerical and experimental validations demonstrate that, by manipulating anisotropic guided wave propagation through metasurfaces, the proposed SSVS framework enables high‐fidelity multi‐source vibration ...
Jianjie Zhang +6 more
wiley +1 more source
Kereskedelem '91 : Budapest, 1991. április
, 2022 Előadások[rend. a] Magyar Gazdasági Kamara Országos Kereskedelmi Szövetség ; [kiad.
core +1 more source
Belügyi SzemleCél: A nyelv természetét érintő kutatások modern eredményeinek felhasználásával annak igazolása, miszerint a rendészettudomány által használt egyes fogalmak jelentésének kutatása szerves részévé, meghatározó elemévé válhat a rendészettudományt ...
Péter Cieleszky
doaj +1 more source
Biotechnológia a GAK intézményeiben : Mezőgazdasági Tudományos Napok
, 2022 Rend. a Gödöllői Agrártudományi Egyetem[közread.
core
Advanced Science, EarlyView.High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao +11 more
wiley +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source