Results 41 to 50 of about 1,233 (214)

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

A Magyar Ferences Rendtartomány a 14. században

Egyháztörténeti Szemle
A ferences rendtartományok első olyan összeírását, mely az egyes provinciák mellett immár név szerint felsorolja azok őrségeit és kolostorait is, Paulinus Venetus pozzuoli püspök készítette el 1340 körül.
Péter Galambosi
doaj   +3 more sources

Trudinger–Moser Inequalities in Fractional Sobolev–Slobodeckij Spaces and Multiplicity of Weak Solutions to the Fractional-Laplacian Equation

Advanced Nonlinear Studies, 2019
In line with the Trudinger–Moser inequality in the fractional Sobolev–Slobodeckij space due to [S. Iula, A note on the Moser–Trudinger inequality in Sobolev–Slobodeckij spaces in dimension one, Atti Accad. Naz. Lincei Rend. Lincei Mat. Appl.
Zhang Caifeng
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

L’eau rend malade et la forêt se venge

Recherches Germaniques
This article builds on recent ecocritical re-readings of plays by Norwegian playwright Henrik Ibsen (1828-1906), while questioning their relevance.
Solenne Guyot
doaj   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Magyar Jezsuiták

Köz-gazdaság, 2020
Kiss Ulrich jezsuita szerzetestől hallottam az alábbi feladványt: „Mely társaság lehet egy 2000 éves cég 450 éves leányvállalata?” A válasz nyilvánvalóan nem a polgári törvénykönyvünk szerinti cégformában működő társaságok között keresendő, hanem ...
István Fábics
doaj  

Ojcowie Jurajscy

Vox Patrum, 1984
L’auteur, qui s’occupe de l’histoire monastique en Occident, rend compte de la Vie des Peres du Jura, l’edition faite par Francois Martine.
Paweł Sczaniecki
doaj   +1 more source

La ville rend libre ? [PDF]

Égypte/Monde arabe, 2012
Selon différents récits historiques, les pays du Maghreb, depuis leur indépendance, ont connu d’importants changements sociaux qui ont eu des répercussions sur l’émancipation des femmes sans pour autant combler les différences structurelles existant entre hommes et femmes.
openaire   +2 more sources