Results 51 to 60 of about 89,917 (257)

Nyelvészeti és népköltészeti, népzenei írások

, 2023
Erdélyi János ; sajtó alá rend. T.
Erdélyi János 1814-1868
core  

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

A magyar nemzetbiztonsági szolgálatok funkciói, különös tekintettel a nemzetbiztonsági érdek jelentőségére

Belügyi Szemle
Cél: A szerző tanulmányában az alkotmányos jogelvekből és a magyar jogszabályi környezet rendelkezéseiből vizsgálja meg a magyar nemzetbiztonsági szolgálatok alkotmányos funkcióit és az állami életben betöltött szerepüket.
István Solti
doaj   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Trudinger–Moser Inequalities in Fractional Sobolev–Slobodeckij Spaces and Multiplicity of Weak Solutions to the Fractional-Laplacian Equation

Advanced Nonlinear Studies, 2019
In line with the Trudinger–Moser inequality in the fractional Sobolev–Slobodeckij space due to [S. Iula, A note on the Moser–Trudinger inequality in Sobolev–Slobodeckij spaces in dimension one, Atti Accad. Naz. Lincei Rend. Lincei Mat. Appl.
Zhang Caifeng
doaj   +1 more source

A pesti Vármegyeháza : Ma a Pest Megyei Tanács székháza

, 2022
2. bőv. kiad.Tóth Antal ; [sajtó alá rend.
Tóth Antal
core  

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

L’eau rend malade et la forêt se venge

Recherches Germaniques
This article builds on recent ecocritical re-readings of plays by Norwegian playwright Henrik Ibsen (1828-1906), while questioning their relevance.
Solenne Guyot
doaj   +1 more source

Ojcowie Jurajscy

Vox Patrum, 1984
L’auteur, qui s’occupe de l’histoire monastique en Occident, rend compte de la Vie des Peres du Jura, l’edition faite par Francois Martine.
Paweł Sczaniecki
doaj   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source