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This spring I attended medical school commencement. Although I am faculty at Boston University School of Medicine and both teach and advise students, I have only participated in this ceremony on one other occasion. This year, however, a close friend was delivering the address, my life partner was receiving a “Humanism in Medicine” prize, and several of
openaire +2 more sources
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Waves and Cycles of Religious Tension in History [PDF]
The notions of «religious awakening» and «religious revival» refer to processes which took place in the history of European civilization. These notions are widely used in academic language and literature.
B. FILIPPOV
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Novel NiCo2O4/MIL-53 (Fe) nanocomposites were synthesized by a hydrothermal preparation approach, which was employed as for the elimination of Congo red (CR) from azo dye effluents.
Bai Sun +9 more
doaj +1 more source
Renewal, Modulation and Superstatistics
We consider two different proposals to generate a time series with the same non-Poisson distribution of waiting times, to which we refer to as renewal and modulation.
Allegrini, Paolo +3 more
core +2 more sources
Impaired contextual modulation of memories in PTSD: an fMRI and psychophysiological study of extinction retention and fear renewal [PDF]
Post-traumatic stress disorder (PTSD) patients display pervasive fear memories, expressed indiscriminately. Proposed mechanisms include enhanced fear learning and impaired extinction or extinction recall. Documented extinction recall deficits and failure
Abelson, James L +6 more
core +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Idealitas eksistensi hakim komisaris terhadap konstruksi peradilan di Indonesia
This study aims to describe one of the political efforts of legal reform in the field of justice in Indonesia. This research describes that the presence or existence of norms that look at commissioner judges in preliminary examinations is part of an ...
Bambang Satriya +2 more
doaj +1 more source
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source

