Results 291 to 300 of about 174,628 (339)

Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1‐7, has an unclear role in cardiac autophagy and hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Bernard D. Keavney, Min Zi, Binh Y. Nguyen, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Susanne S. Hille, Elizabeth J. Cartwright, Oliver J. Müller, Honglin Xu, Sam Butterworth, Xin Wang   +16 more
wiley   +1 more source

Dysregulation of the renin-angiotensin system in vascular dementia. [PDF]

Brain Pathol
Tayler HM, Skrobot OA, Baron DH, Kehoe PG, Miners JS.   +4 more
europepmc   +1 more source

The thoracic perivascular adipose tissue spontaneously induces vasoconstriction through activation of α1‐adrenoceptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira, José Eduardo da Silva‐Santos   +1 more
wiley   +1 more source

Reductions in renin-angiotensin system inhibitors following hospitalization for heart failure. [PDF]

ESC Heart Fail
Goyal P, Chen L, Lau JD, Rosenson RS, Levitan EB.   +4 more
europepmc   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

Renin Is Essential for Angiotensin II Formation in the Brain

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
André F. Rodrigues, Oliver Domenig, Ingrid M. Garrelds, A.H. Jan Danser, Natalia Alenina, Marko Poglitsch, Michael Bader   +6 more
doaj   +1 more source

Evaluating the risks and benefits of continuing <i>versus</i> withholding renin-angiotensin system inhibitors: a systematic review and meta-analysis with trial sequential analysis. [PDF]

BJA Open
Shalabi L, Ibrahim A, Zreigh S, Rifai M, Ramadan S, Arafa MA, Mustafa OM, Ansab M, Krayem MF, Elsabbagh I, Mash'al NH, Waleed S, Legrand M.   +12 more
europepmc   +1 more source

Clinical Significance of Skeletal Fat‐to‐Muscle Ratio in Idiopathic Hyperaldosteronism

Clinical Endocrinology, EarlyView.
ABSTRACT Objective The objective of this study is to evaluate the correlation between the fat‐to‐muscle ratio (FMR) and insulin resistance (IR) with aldosterone production among patients with idiopathic hyperaldosteronism (IHA). Methods Patients with primary aldosteronism were screened from those with secondary hypertension and then subtyped via ...
Yuhe Jiang, Dan Li, Cassie Chen Cao, Wenjing Feng, Ruidong Liu, Yinfei Xu, Caixia Cao   +6 more
wiley   +1 more source

Kidney Renin-Angiotensin System: Lost in a RAS Cascade. [PDF]

Hypertension
Crowley SD, Navar LG, Prieto MC, Gurley SB, Coffman TM.   +4 more
europepmc   +1 more source

Ramadan Fasting Improves Health‐Related Quality of Life in Patients With Secondary Adrenal Insufficiency: A Prospective Interventional Case‐Control Study

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Intermittent fasting (IF) exposes patients with adrenal insufficiency (AI) to complications related to undertreatment. We aimed to determine the effect of IF during Ramadan on the quality of life of patients with secondary adrenal insufficiency (SAI) compared to healthy controls.
Mariam Mabrouk, Melika Chihaoui, Jameleddine Sta, Chayma Belhadj Slimane, Ibtissem Oueslati, Meriem Yazidi, Fatma Chaker   +6 more
wiley   +1 more source