Results 291 to 300 of about 860,286 (378)

Antibiotic Use and Risk of Microscopic Colitis in Older Adults: A Nationwide Self‐Controlled Case Series Study

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 9, Page 1500-1507, May 2025.
In adults aged 65 and older, antibiotic use was linked to a higher risk of microscopic colitis. However, a negative control analysis suggests this association is likely due to detection bias during diagnostic workups, rather than a direct causal relationship.
Máté Szilcz, Jonas W. Wastesson, David Bergman, Kristina Johnell, Jonas F. Ludvigsson   +4 more
wiley   +1 more source

Treat or not treat COVID-19 with combined renin-angiotensin system and neprilysin inhibition: Have we found a solution? [PDF]

Eur J Heart Fail
Emrich IE, Böhm M.
europepmc   +1 more source

Chimeric renin-angiotensin system elevates blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes by their synergistic reaction.

, 1993
Akiyoshi Fukamizu, Kazuo Murakami
openalex   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Identification of a novel prognostic and therapeutic prediction model in clear cell renal carcinoma based on Renin-angiotensin system related genes. [PDF]

Front Endocrinol (Lausanne)
Chang Q, Zhao S, Sun J, Guo W, Yang L, Qiu L, Zhang N, Fan Y, Liu J.   +8 more
europepmc   +1 more source

Involvement of the sympathetic nervous and the renin-angiotensin systems in hypertensive responses to NG-nitro-L-arginine in anesthetized dogs

, 1992
Tsutomu Nakahara, Ken-Ichiro Iwamoto, Kunio Ishji, Koichi Nakayama   +3 more
openalex   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Inhibition of renin-angiotensin system attenuates type I alveolar epithelial cell necroptosis in rats after hyperbaric hyperoxic exposure. [PDF]

Front Med (Lausanne)
Han C, Zhang P, Liu Y, Xu J, Yu X, Wen Y, Wang S, Liu W.   +7 more
europepmc   +1 more source

Hypotensive and diuretic effects of renin-angiotensin system (RAS) blockers; Physiological role of angiotensin II (AII)

, 1992
Hideki Okunishi, Kenji Ishii, Hiroshi Sakonjo, Yuko Oka, Mizuo Miyazaki   +4 more
openalex   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source