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Renin–Angiotensin System [PDF]
, 2015 The rennin-angiotensin system (RAS) regulates blood pressure, fluid volume, and sodium and potassium balance (Ferrario and Strawn 2006). Dysregulation of RAS system is implicated in cardiovascular disease – hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, stroke, congestive heart failure – and renal disease (reviewed ...
Liomar A. A. Neves +2 more
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2011
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nature, there are convincing data that the renin-angiotensin system (RAS) is a major mediator of renal ...
Lai, KN, Tang, SCW, Leung, JCK
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Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nature, there are convincing data that the renin-angiotensin system (RAS) is a major mediator of renal ...
Lai, KN, Tang, SCW, Leung, JCK
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Pharmacological Reviews, 1965
The major actions of this system seem to be exerted at an extracellular level even though there are strong suggestions that some intracellular effects may also be important.
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The major actions of this system seem to be exerted at an extracellular level even though there are strong suggestions that some intracellular effects may also be important.
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Medical Clinics of North America, 1987
The renin-angiotensin systems are important regulators of cardiovascular homeostasis and participate in a variety of pathological conditions. Recent advances have not only clarified the functioning of the systemic renin cascade but have also indicated the importance of the generation of angiotensin in tissues.
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The renin-angiotensin systems are important regulators of cardiovascular homeostasis and participate in a variety of pathological conditions. Recent advances have not only clarified the functioning of the systemic renin cascade but have also indicated the importance of the generation of angiotensin in tissues.
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The Ontogeny of the Renin-Angiotensin System
Clinics in Perinatology, 1981This article reviews the seven components of the renin-angiotensin system —renin, renin substrate, angiotensin I, converting enzyme, angiotensin II, angiotensin III, and angiotensinases — and emphasizes current knowledge of this system during development.
Pedro A. Jose +2 more
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C. The renin-angiotensin system. A history and review of the renin-angiotensin system
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1969An outline of the development of knowledge of the renin-angiotensin system is given, and the nature of the enzyme renin, its site within the kidney as well as in other organs, and its action on plasma substrate to form first the decapeptide which is converted to the biologically active octapeptide, are considered.
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Trends in Pharmacological Sciences, 1987
Abstract In this article, M. B. Vallotton reviews the recent advances in our knowledge of the biochemistry of renin which have led to a better understanding of the physiological and pathophysiological conditions in which this system plays a role. These advances have led to the design of new drugs interfering with the renin-angiotensin system for ...
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Abstract In this article, M. B. Vallotton reviews the recent advances in our knowledge of the biochemistry of renin which have led to a better understanding of the physiological and pathophysiological conditions in which this system plays a role. These advances have led to the design of new drugs interfering with the renin-angiotensin system for ...
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2008
Over 100 years have passed since the discovery of renin as a “pressor substance” in 1898 by Robert Tigerstedt at Karolinska Institute. The 48-page publication “Niere und Kreislauf” in Skandinavisches Archiev fur Physiologie in 1898 by Tiegerstedt and Bergman detailed their meticulous approaches, even including the design of a flow meter to measure ...
James R. Sowers +1 more
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Over 100 years have passed since the discovery of renin as a “pressor substance” in 1898 by Robert Tigerstedt at Karolinska Institute. The 48-page publication “Niere und Kreislauf” in Skandinavisches Archiev fur Physiologie in 1898 by Tiegerstedt and Bergman detailed their meticulous approaches, even including the design of a flow meter to measure ...
James R. Sowers +1 more
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The renin-angiotensin system and atherosclerosis
Current Hypertension Reports, 2006Atherosclerosis is an insidious and complex disease of large- and medium-sized arteries. The primum movens of the disease is characterized by co-localization of lipids, inflammatory cells, and fibrous elements within the intima of vessels. Starting as a "fatty streak," the disease evolves over decades into complex lesions that can progress toward a ...
Daniel Hayoz, Lucia Mazzolai
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The Pulmonary Renin-Angiotensin System
Current Pharmaceutical Design, 2003The circulating renin-angiotensin system (RAS) has a well-described role in circulatory homeostasis. Recently, local tissue-based RAS have also been described which appear to play a key role in the injury/repair response. The expression of RAS components and the elevation of angiotensin converting enzyme in a number of interstitial lung diseases ...
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