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Alternative Renin-Angiotensin System
HypertensionThe renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, which activates its AT 1 receptor, thereby increasing blood ...
Michael Bader +4 more
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Journal of Hypertension, 2011
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nature, there are convincing data that the renin-angiotensin system (RAS) is a major mediator of renal ...
Lai, KN, Tang, SCW, Leung, JCK
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Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nature, there are convincing data that the renin-angiotensin system (RAS) is a major mediator of renal ...
Lai, KN, Tang, SCW, Leung, JCK
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Annual Review of Physiology, 1978
Since the discovery of renin 80 years ago, there have been remarkable advances in our understanding of the renin-angiotensin system. The system as it is known today is summarized in Figure 1. Angiotensin III, the active component of the system, has several important physiological actions.
I A, Reid, B J, Morris, W F, Ganong
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Since the discovery of renin 80 years ago, there have been remarkable advances in our understanding of the renin-angiotensin system. The system as it is known today is summarized in Figure 1. Angiotensin III, the active component of the system, has several important physiological actions.
I A, Reid, B J, Morris, W F, Ganong
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Cardiac Renin–Angiotensin System
American Journal of Hypertension, 1989Based on molecular, biological, biochemical, and pharmacological data, evidence is presented for a cardiac renin-angiotensin system. Using radiolabeled cRNA probes prepared from specific cDNA fragments, we were able to document renin and angiotensinogen gene expression in atria and ventricles of the rat heart by Northern blot and liquid hybridization ...
W, Linz +3 more
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Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers.
JAMA cardiology, 2020The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already surpassed the com-bined mortality inflicted by the severe acute respira-torysyndrome(SARS)epidemicof2002and2003and the ...
Chirag P Bavishi, T. Maddox, F. Messerli
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Pharmacological Reviews, 1965
The major actions of this system seem to be exerted at an extracellular level even though there are strong suggestions that some intracellular effects may also be important.
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The major actions of this system seem to be exerted at an extracellular level even though there are strong suggestions that some intracellular effects may also be important.
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Tissue renin angiotensin systems
Medical Clinics of North America, 2004The RAAS is a powerful regulator of vascular tone and intravascular volume and of tissue architecture and a variety of other functions. The recent appreciation of the immunoregulatory role of angiotensin II and its possible involvement in the genesis of atherosclerosis and in plaque rupture all speak to the wide-ranging physiologic and pathophysiologic
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Medical Clinics of North America, 1987
The renin-angiotensin systems are important regulators of cardiovascular homeostasis and participate in a variety of pathological conditions. Recent advances have not only clarified the functioning of the systemic renin cascade but have also indicated the importance of the generation of angiotensin in tissues.
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The renin-angiotensin systems are important regulators of cardiovascular homeostasis and participate in a variety of pathological conditions. Recent advances have not only clarified the functioning of the systemic renin cascade but have also indicated the importance of the generation of angiotensin in tissues.
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Renin-angiotensin-aldosterone system
European Journal of Clinical Pharmacology, 1980There is increased activity of the renin, angiotensin, aldosterone (RAA) system in infancy and childhood. An inverse relationship between plasma renin, aldosterone and age has been demonstrated. In childhood hypertension due to renovascular disease or pyelonephritic scarring peripheral plasma renin is increased.
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2008
Over 100 years have passed since the discovery of renin as a “pressor substance” in 1898 by Robert Tigerstedt at Karolinska Institute. The 48-page publication “Niere und Kreislauf” in Skandinavisches Archiev fur Physiologie in 1898 by Tiegerstedt and Bergman detailed their meticulous approaches, even including the design of a flow meter to measure ...
L. Romayne Kurukulasuriya, James Sowers
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Over 100 years have passed since the discovery of renin as a “pressor substance” in 1898 by Robert Tigerstedt at Karolinska Institute. The 48-page publication “Niere und Kreislauf” in Skandinavisches Archiev fur Physiologie in 1898 by Tiegerstedt and Bergman detailed their meticulous approaches, even including the design of a flow meter to measure ...
L. Romayne Kurukulasuriya, James Sowers
openaire +1 more source