Results 231 to 240 of about 240,790 (255)
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1989
In the last decade renin research progressed rapidly. This was due to the development of protein and peptide chemistry, modern immunology and molecular biology.
Shinjiro Muneta +3 more
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In the last decade renin research progressed rapidly. This was due to the development of protein and peptide chemistry, modern immunology and molecular biology.
Shinjiro Muneta +3 more
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American Journal of Obstetrics and Gynecology, 1988
I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
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I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
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The Renin Prosequence Enhances Constitutive Secretion of Renin and Optimizes Renin Activity
Current Neurovascular Research, 2011Renin is cleaved from its precursor prorenin into mature renin. We investigated the impact of the renin proregion on the generation and secretion of enzymatically active renin. We compared the effects of the following sequences of human prorenin with those of wild type prorenin[1-383]: prosequence [1-43], hinge sequence [1-62], Des[1-43]prorenin ...
Juerg Nussberger +3 more
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STRUCTURE OF HUMAN RENIN AND EXPRESSION OF THE RENIN GENE
Clinical and Experimental Pharmacology and Physiology, 1984SUMMARY1. The amino acid sequence of human renin was identified for the first time. This was determined from the nucleotide sequence of exons in the human renin gene identified in a genomic library by recombinant DNA techniques.2. Examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique Leu10‐Val11 bond of ...
Brian J. Morris +7 more
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Human renin gene of renin-secreting tumor
Gene, 1986A large amount of renin mRNA was found to be expressed in the juxtaglomerular cell (JGC) tumor, as determined by Northern analysis. We have isolated the long 5'-flanking region of the human renin gene from the tumor, and characterized the promoter region with respect to nucleotide (nt) sequence and mRNA transcription start point.
Kazuo Murakami +5 more
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Renin Release from Renin Granules in the Dog
Clinical Science, 19781. Renin release from isolated dog renin granules was limited to within 20% of the total renin during incubation at 37°C in isotonic medium and did not depend on the external concentration of renin. 2. Although the renin granules were osmotically and mechanically fragile, they were quite stable at 0°C in isotonic medium. 3.
T. Higashio +2 more
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2016
Renin is the initiative enzyme for the renin-angiotensin system. It is synthesized mainly in the juxta-glomerular apparatus and secreted in to the circulation in response to hypotension and hypernatremia. Renin cleaves angiotensin I (Ang I) from angiotensinogen by recognizing the [HPF]-domain on Ang I.
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Renin is the initiative enzyme for the renin-angiotensin system. It is synthesized mainly in the juxta-glomerular apparatus and secreted in to the circulation in response to hypotension and hypernatremia. Renin cleaves angiotensin I (Ang I) from angiotensinogen by recognizing the [HPF]-domain on Ang I.
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[From the renin gene to renin inhibitors].
Annales d'endocrinologie, 1986The only known action of renin is the hydrolysis of angiotensinogen into angiotensin I. Renin is synthesized as an inactive precursor, preprorenin. The processing of prorenin into active renin occurs after the clivage of a profragment, just after a dibasic pair of amino-acids.
P, Corvol, J, Ménard
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Medicinal Research Reviews, 1990
Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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JAMA: The Journal of the American Medical Association, 1979
To the Editor.— The article by Laragh and associates inTHE JOURNAL(241:151, 1979) concerning renin profiling for the diagnosis and treatment of hypertensive patients puts the renin-angiotensin system in a unique position in regard to other humoral substances.
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To the Editor.— The article by Laragh and associates inTHE JOURNAL(241:151, 1979) concerning renin profiling for the diagnosis and treatment of hypertensive patients puts the renin-angiotensin system in a unique position in regard to other humoral substances.
openaire +3 more sources