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Renin report: spotlight on Renin: therapeutic opportunities for Renin inhibitors.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 2006 openaire +1 more source
A rare case of apparent mineralocorticoid excess induced by chronic liquorice ingestion. [PDF]
Endocrinol Diabetes Metab Case RepRoy A, Mullins K.
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Human liver enzyme pattern in thyrotoxicosis and hypothyrodism [PDF]
, 1970 Bachmaier, B. +4 more
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Physiology, 2007
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the ...
Schweda, Frank +4 more
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The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the ...
Schweda, Frank +4 more
openaire +3 more sources
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982
Although the brain contains cathepsins at high concentrations which exhibit a non-specific renin-like activity at acidic pH, the presence of specific renin in the brain has been demonstrated by characterizing its specific properties. Renin was separated from cathepsin by affinity chromatography on casein-Sepharose.
T, Inagami +6 more
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Although the brain contains cathepsins at high concentrations which exhibit a non-specific renin-like activity at acidic pH, the presence of specific renin in the brain has been demonstrated by characterizing its specific properties. Renin was separated from cathepsin by affinity chromatography on casein-Sepharose.
T, Inagami +6 more
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Inactive Renin — A Renin Proenzyme?
1977Human plasma contains an inactive form of renin with a m.w. of 55,000, as against around 40,000 for active human renin. After acidification to pH 3.0 or incubation with trypsin, the inactive renin becomes more active and the molecular weight falls to that of active renin.
B J, Leckie, A, McConnell, J, Jordan
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Pharmaceutical Research, 1987
Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Renin, Renin Inhibition and Antihypertensive Therapy
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1983Research over the last 25 years established the renin-angiotensin-aldosterone system's important role in electrolyte and blood pressure homeostasis as well as in the pathophysiology of hypertension for which renin suppressive drugs, angiotensin antagonists and converting enzyme inhibitors provided selective pharmacological tools.
F. R. Bühler +1 more
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Cardiovascular Drugs and Therapy, 1995
Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been hampered by a variety of pharmacologic problems, most notably the poor oral bioavailability of these ...
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Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been hampered by a variety of pharmacologic problems, most notably the poor oral bioavailability of these ...
openaire +2 more sources