Results 311 to 320 of about 261,257 (360)
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Human renin gene of renin-secreting tumor
Gene, 1986A large amount of renin mRNA was found to be expressed in the juxtaglomerular cell (JGC) tumor, as determined by Northern analysis. We have isolated the long 5'-flanking region of the human renin gene from the tumor, and characterized the promoter region with respect to nucleotide (nt) sequence and mRNA transcription start point.
A, Fukamizu +5 more
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Current Opinion in Nephrology & Hypertension, 2006
Initial attempts to inhibit renin in humans have faced numerous difficulties. Molecular modeling and X-ray crystallography of the active site of renin have led to the development of new orally active renin inhibitors, such as aliskiren. Recent preclinical and clinical data suggest that this drug may be of value for treating patients with cardiovascular
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Initial attempts to inhibit renin in humans have faced numerous difficulties. Molecular modeling and X-ray crystallography of the active site of renin have led to the development of new orally active renin inhibitors, such as aliskiren. Recent preclinical and clinical data suggest that this drug may be of value for treating patients with cardiovascular
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[From the renin gene to renin inhibitors].
Annales d'endocrinologie, 1986The only known action of renin is the hydrolysis of angiotensinogen into angiotensin I. Renin is synthesized as an inactive precursor, preprorenin. The processing of prorenin into active renin occurs after the clivage of a profragment, just after a dibasic pair of amino-acids.
P, Corvol, J, Ménard
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The Journal of Clinical Endocrinology & Metabolism, 1977
Renin activity, concentration, substrate and reactivity were determined in normal subjects as well as in hypertensive subjects with suppressed and normal plasma renin activity. Renin substrate measurements were similar in all groups. Renin reactivity, a measure of circulating modifiers of the renin reaction, was significantly increased in both ...
W J, McDonald, E L, Cohen, J W, Conn
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Renin activity, concentration, substrate and reactivity were determined in normal subjects as well as in hypertensive subjects with suppressed and normal plasma renin activity. Renin substrate measurements were similar in all groups. Renin reactivity, a measure of circulating modifiers of the renin reaction, was significantly increased in both ...
W J, McDonald, E L, Cohen, J W, Conn
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Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1959
The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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Renin, Prorenin, and the (Pro)Renin Receptor
2009The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin angiotensin system (RAS) and has brought prorenin back in the spotlight.
Genevieve Nguyen, Aurelie Contrepas
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Renin, (pro)renin and receptor: an update
Clinical Science, 2010PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/2. However the gene encoding for PRR is named ATP6ap2 (ATPase 6 accessory protein 2) because PRR was initially found ...
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Comprehensive Physiology, 1999
Abstract The sections in this article are: The Renin Paper A blood pressure‐raising substance is formed in the kidneys and passed into the blood Time course of the pressure elevation ...
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Abstract The sections in this article are: The Renin Paper A blood pressure‐raising substance is formed in the kidneys and passed into the blood Time course of the pressure elevation ...
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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Nature Reviews Immunology, 2021Zivile Bekassy +2 more
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