Results 311 to 320 of about 221,319 (346)
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Renin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients*
Critical Care Medicine, 2019Objectives: To characterize renin in critically ill patients. Renin is fundamental to circulatory homeostasis and could be a useful marker of tissue-perfusion.
P. Gleeson +8 more
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Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1959
The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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Clinical and Experimental Pharmacology and Physiology, 1986
SUMMARY1. New gene data for three aspartyl proteases (human renin, mouse renin and human pepsin) permitted closer analysis of the gene duplication and fusion hypothesis for the evolution of this family of enzymes.2. Alignment of sequences in the hemilobes of human pepsin revealed only weak homology in amino acid sequences.
Brain J. Morris, Daniel F. Catanzaro
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SUMMARY1. New gene data for three aspartyl proteases (human renin, mouse renin and human pepsin) permitted closer analysis of the gene duplication and fusion hypothesis for the evolution of this family of enzymes.2. Alignment of sequences in the hemilobes of human pepsin revealed only weak homology in amino acid sequences.
Brain J. Morris, Daniel F. Catanzaro
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Archives of Internal Medicine, 1973
Renin plays a significant role in normal and pathophysiologic states. Among the various factors affecting renin secretion are the afferent arteriole acting as a baroreceptor, the macula densa as a sensor of sodium delivery to the distal tubule, and the adrenergic nervous system.
Jay H. Stein, Thomas F. Ferris
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Renin plays a significant role in normal and pathophysiologic states. Among the various factors affecting renin secretion are the afferent arteriole acting as a baroreceptor, the macula densa as a sensor of sodium delivery to the distal tubule, and the adrenergic nervous system.
Jay H. Stein, Thomas F. Ferris
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Renin, (pro)renin and receptor: an update
Clinical Science, 2010PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/2. However the gene encoding for PRR is named ATP6ap2 (ATPase 6 accessory protein 2) because PRR was initially found ...
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Nephron, 1975
The factors involved in renin release have been extensively evaluated. The primary determinants are the transmural pressure at the afferent arteriole, sodium delivery to the macula densa, and the activity of the adrenergic nervous system. Other possible factors include circulating catecholamines, the serum and cerebrospinal fluid sodium concentration ...
Jay H. Stein +2 more
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The factors involved in renin release have been extensively evaluated. The primary determinants are the transmural pressure at the afferent arteriole, sodium delivery to the macula densa, and the activity of the adrenergic nervous system. Other possible factors include circulating catecholamines, the serum and cerebrospinal fluid sodium concentration ...
Jay H. Stein +2 more
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1989
In the last decade renin research progressed rapidly. This was due to the development of protein and peptide chemistry, modern immunology and molecular biology.
Shinjiro Muneta +3 more
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In the last decade renin research progressed rapidly. This was due to the development of protein and peptide chemistry, modern immunology and molecular biology.
Shinjiro Muneta +3 more
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American Journal of Obstetrics and Gynecology, 1988
I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
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I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
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The Renin Prosequence Enhances Constitutive Secretion of Renin and Optimizes Renin Activity
Current Neurovascular Research, 2011Renin is cleaved from its precursor prorenin into mature renin. We investigated the impact of the renin proregion on the generation and secretion of enzymatically active renin. We compared the effects of the following sequences of human prorenin with those of wild type prorenin[1-383]: prosequence [1-43], hinge sequence [1-62], Des[1-43]prorenin ...
Juerg Nussberger +3 more
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STRUCTURE OF HUMAN RENIN AND EXPRESSION OF THE RENIN GENE
Clinical and Experimental Pharmacology and Physiology, 1984SUMMARY1. The amino acid sequence of human renin was identified for the first time. This was determined from the nucleotide sequence of exons in the human renin gene identified in a genomic library by recombinant DNA techniques.2. Examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique Leu10‐Val11 bond of ...
Brian J. Morris +7 more
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