Results 321 to 330 of about 221,319 (346)
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Human renin gene of renin-secreting tumor
Gene, 1986A large amount of renin mRNA was found to be expressed in the juxtaglomerular cell (JGC) tumor, as determined by Northern analysis. We have isolated the long 5'-flanking region of the human renin gene from the tumor, and characterized the promoter region with respect to nucleotide (nt) sequence and mRNA transcription start point.
Kazuo Murakami +5 more
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Renin Release from Renin Granules in the Dog
Clinical Science, 19781. Renin release from isolated dog renin granules was limited to within 20% of the total renin during incubation at 37°C in isotonic medium and did not depend on the external concentration of renin. 2. Although the renin granules were osmotically and mechanically fragile, they were quite stable at 0°C in isotonic medium. 3.
T. Higashio +2 more
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2016
Renin is the initiative enzyme for the renin-angiotensin system. It is synthesized mainly in the juxta-glomerular apparatus and secreted in to the circulation in response to hypotension and hypernatremia. Renin cleaves angiotensin I (Ang I) from angiotensinogen by recognizing the [HPF]-domain on Ang I.
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Renin is the initiative enzyme for the renin-angiotensin system. It is synthesized mainly in the juxta-glomerular apparatus and secreted in to the circulation in response to hypotension and hypernatremia. Renin cleaves angiotensin I (Ang I) from angiotensinogen by recognizing the [HPF]-domain on Ang I.
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[From the renin gene to renin inhibitors].
Annales d'endocrinologie, 1986The only known action of renin is the hydrolysis of angiotensinogen into angiotensin I. Renin is synthesized as an inactive precursor, preprorenin. The processing of prorenin into active renin occurs after the clivage of a profragment, just after a dibasic pair of amino-acids.
P, Corvol, J, Ménard
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Medicinal Research Reviews, 1990
Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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JAMA: The Journal of the American Medical Association, 1979
To the Editor.— The article by Laragh and associates inTHE JOURNAL(241:151, 1979) concerning renin profiling for the diagnosis and treatment of hypertensive patients puts the renin-angiotensin system in a unique position in regard to other humoral substances.
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To the Editor.— The article by Laragh and associates inTHE JOURNAL(241:151, 1979) concerning renin profiling for the diagnosis and treatment of hypertensive patients puts the renin-angiotensin system in a unique position in regard to other humoral substances.
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Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982
Although the brain contains cathepsins at high concentrations which exhibit a non-specific renin-like activity at acidic pH, the presence of specific renin in the brain has been demonstrated by characterizing its specific properties. Renin was separated from cathepsin by affinity chromatography on casein-Sepharose.
T, Inagami +6 more
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Although the brain contains cathepsins at high concentrations which exhibit a non-specific renin-like activity at acidic pH, the presence of specific renin in the brain has been demonstrated by characterizing its specific properties. Renin was separated from cathepsin by affinity chromatography on casein-Sepharose.
T, Inagami +6 more
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Essential hypertension: renin and aldosterone, heart attack and stroke.
New England Journal of Medicine, 1972In 219 patients with essential hypertension, aldosterone excretion and plasma renin activity were related to daily sodium excretion and compared to a nomogram drawn from 52 normal volunteers studied over the same continuous range of sodium balance ...
H. Brunner +7 more
semanticscholar +1 more source
Cardiovascular Drugs and Therapy, 1995
Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been hampered by a variety of pharmacologic problems, most notably the poor oral bioavailability of these ...
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Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been hampered by a variety of pharmacologic problems, most notably the poor oral bioavailability of these ...
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002
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