Results 31 to 40 of about 169,488 (234)
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
THE DEVELOPMENT OF THE PLEKHANOV RUSSIAN ACADEMY OF ECONOMICS IN THE LATE 1980s – EARLY 2000s
Вестник Российского экономического университета имени Г. В. Плеханова, 2018 The article describes key problems, which the Russian Plekhanov Academy of Economics faced during the years of reforms and steps taken by the Academy administration in the late 1980s – early 2000s in order to overcome them and reorganize the Academy ...
Irina M. Kornilova, Mikhail V. Sokolov
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Вестник Российского экономического университета имени Г. В. Плеханова, 2018 The development of the Public Health system as a field of public health reproduction is a priority objective of any social state and the Russian Federation according to Article 7 of the Constitution is a social state.
Oleg E. Karpov +4 more
doaj +1 more source
Frontiers in Human Neuroscience, 2020 In patients with gliomas, motor deficits are not always observed, even though tumor cells infiltrate into the motor area. Currently, it is recognized that this phenomenon can occur through the neuroplasticity potential.
Riho Nakajima +2 more
doaj +1 more source
A New Paradigm for the Integrated Sustainability and Management of the Tehran Metropolis: Capital City Reorganization or Relocation [PDF]
برنامهریزی توسعه شهری و منطقهای, 2018 It seems that we are not in harmony with the changes of the Tehran metropolis as the capital city of Iran. We often encounter what Cowell and Owens call an implementation deficit.
Mahmood Jomehpour
doaj +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Неотложная медицинская помощь, 2016 The article summarizes changes in the structure of the N.V. Sklifosovsky Research Institute for Emergency Medicine. The analysis of major indicators of therapeutic practice showed the effectiveness of measures for the foundation of new departments and ...
M. Sh. Khubutiya +6 more
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