Results 51 to 60 of about 621,354 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

THE DEVELOPMENT OF THE PLEKHANOV RUSSIAN ACADEMY OF ECONOMICS IN THE LATE 1980s – EARLY 2000s

Вестник Российского экономического университета имени Г. В. Плеханова, 2018
The article describes key problems, which the Russian Plekhanov Academy of Economics faced during the years of reforms and steps  taken by the Academy administration in the late 1980s – early 2000s in order to overcome them and reorganize the Academy ...
Irina M. Kornilova, Mikhail V. Sokolov
doaj   +1 more source

Vertical vs. Adiabatic Ionization Energies in Solution and Gas-Phase: Probing Ionization-Induced Reorganization in Conformationally-Mobile Bichromophoric Actuators Using Photoelectron Spectroscopy, Electrochemistry and Theory [PDF]

, 2018
Ionization-induced structural and conformational reorganization in various π-stacked dimers and covalently linked bichromophores is relevant to many processes in biological systems and functional materials. In this work, we examine the role of structural,
Ivanov, Maxim Vadimovich, Rathore, Rajendra, Reid, Scott A., Wang, Denan, Zhang, Depeng   +4 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

LEGAL BASIS AND SPECIFIC FEATURES OF FEDERAL INSTITUTIONS OF PUBLIC HEALTH REORGANIZATION ACCORDING TO RUSSIAN CIVIL LEGISLATION

Вестник Российского экономического университета имени Г. В. Плеханова, 2018
The development of the Public Health system as a field of public health reproduction is a priority objective of any social state and the Russian Federation according to Article 7 of the Constitution is a social state.
Oleg E. Karpov, Irina V. Fadeeva, Dmitriy N. Nikitenko, Victor V. Tretyakov, Ekaterina M. Nushtaeva   +4 more
doaj   +1 more source

Motor Functional Reorganization Is Triggered by Tumor Infiltration Into the Primary Motor Area and Repeated Surgery

Frontiers in Human Neuroscience, 2020
In patients with gliomas, motor deficits are not always observed, even though tumor cells infiltrate into the motor area. Currently, it is recognized that this phenomenon can occur through the neuroplasticity potential.
Riho Nakajima, Masashi Kinoshita, Mitsutoshi Nakada   +2 more
doaj   +1 more source

A New Paradigm for the Integrated Sustainability and Management of the Tehran Metropolis: Capital City Reorganization or Relocation [PDF]

برنامه‌ریزی توسعه شهری و منطقه‌ای, 2018
It seems that we are not in harmony with the changes of the Tehran metropolis as the capital city of Iran. We often encounter what Cowell and Owens call an implementation deficit.
Mahmood Jomehpour
doaj   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

ANALYSIS OF CLINICAL AND ORGANIZATIONAL ACTIVITIES IN THE N.V.SKLIFOSOVSKY RESEARCH INSTITUTE FOR EMERGENCY MEDICINE IN 2005–2015

Неотложная медицинская помощь, 2016
The article summarizes changes in the structure of the N.V. Sklifosovsky Research Institute for Emergency Medicine. The analysis of major indicators of therapeutic practice showed the effectiveness of measures for the foundation of new departments and ...
M. Sh. Khubutiya, N. A. Karasev, E. V. Kislukhina, V. A. Vasilyev, B. L. Kurilin, A. B. Medvedeva, I. V. Kiselevskaya-Babinina   +6 more
doaj  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source