Results 201 to 210 of about 53,784 (251)
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Renal tubular cell death and inflammation response are regulated by the MAPK-ERK-CREB signaling pathway under hypoxia-reoxygenation injury

Journal of Receptor and Signal Transduction Research, 2019
Context: Cell death and inflammation response have been found to the primary features of acute kidney injury. Objective: The aim of our study is to figure out the molecular mechanism by which hypoxia-reoxygenation injury affects the viability of tubular ...
Q. Dong   +5 more
semanticscholar   +1 more source

Oxidative Changes in Hypoxic-Reoxygenated Rabbit Heart: A Consequence of Hypoxia Rather Than Reoxygenation

Free Radical Research Communications, 1991
Tissue changes consistent with oxidative damage in hypoxic/reoxygenated heart tissue have not been well documented. We recently reported that oxidative perturbations were evident in isolated-perfused rat heart tissue subjected to as little as 10 min hypoxia and that these changes were not exacerbated by reoxygenation.
Y, Park, J P, Kehrer
openaire   +2 more sources

Hypoxia/Reoxygenation Affects Endotoxin Tolerance

Journal of Surgical Research, 1995
Pretreatment of animals with sublethal doses of endotoxin renders them tolerant to subsequent endotoxin challenge. Tissue hypoxia following infection may potentiate the immune response to injury. To evaluate the effect of hypoxia/reoxygenation (H/R) on endotoxin tolerance by macrophages, adult CBA mice were pretreated with 10 micrograms/animal of LPS ...
G, Arya, V F, Garcia
openaire   +2 more sources

Integrated metabolomic and transcriptomic analysis of brain energy metabolism in the male Oriental river prawn (Macrobrachium nipponense) in response to hypoxia and reoxygenation.

Environmental Pollution, 2018
Hypoxia is as an endocrine disruptor, and, in crustaceans, the energy metabolic consequences of hypoxia in the brain tissue are still poorly understood.
Sheng-Ming Sun   +4 more
semanticscholar   +1 more source

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

International Journal of Radiation Oncology*Biology*Physics, 1994
To test the hypothesis that, following preferential killing of tumor hypoxic cells, the fraction of hypoxic cells in the tumor will reestablish itself to pretreatment levels (rehypoxiation) with the same kinetics as for reoxygenation.Mouse squamous cell carcinoma VII (SCCVII) tumors were treated with a single dose of 10 Gy or a single dose of the ...
I H, Kim, J M, Brown
openaire   +2 more sources

Reoxygenation-induced rigor-type contracture

Journal of Molecular and Cellular Cardiology, 2003
The hypothesis tested was that reoxygenation-induced contracture of myocardial cells, a form of reperfusion injury, can be due to a rigor-type mechanism. Isolated adult cardiomyocytes were exposed to 30- or 60-min anoxia (pH 6.4) and reoxygenation (pH 7.4). In cardiomyocytes, cytosolic Ca(2+) and cell length, and in isolated rat hearts left ventricular
Yury, Ladilov   +8 more
openaire   +2 more sources

Tumor Reoxygenation and Postirradiation Vascular Changes

Radiology, 1978
Postirradiation reoxygenation kinetics of the Walker 256 carcinoma were examined and related to radiation-induced changes in tumor vascular functions. Changes in the hypoxic cell component of irradiated Walker tumors may occur by two mechanisms. Reoxygenation of previously hypoxic cells may be due to an increased rate of blood flow in some parts of the
J J, Clement, N, Tanaka, C W, Song
openaire   +2 more sources

Sodium pump failure in hypoxia and reoxygenation

Journal of Molecular and Cellular Cardiology, 1992
Sodium pump measurements have not been previously documented in the intact heart close to the onset of irreversible injury in hypoxia and reoxygenation. In the present experiments, Rb+ uptake was measured in the presence and absence of ouabain in Langendorff-perfused rat hearts. In the presence of ouabain, Rb+ uptake was increased after 10 min hypoxia (
openaire   +2 more sources

Hypoxia and reoxygenation in human melanoma xenografts

International Journal of Radiation Oncology*Biology*Physics, 1989
Tumor hypoxia and reoxygenation pattern following single dose (10.0 Gy) and fractionated (7 fractions of 2.0 Gy, 1 fraction per day) irradiation were studied in five human melanoma xenograft lines using the paired survival curve method. The hypoxic fractions differed significantly among the melanoma lines; they were found to be 6 +/- 3% (E.E.), 22 ...
openaire   +2 more sources

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