Results 91 to 100 of about 1,567,787 (319)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Blanchard Auto Repair advertisement, circa 1925 [PDF]

, 1925
In 1923 the first mention of Blanchard Auto Repair Company appeared in The Seattle Daily Times, as the builders of a special "California top," a form of early pillarless hardtop designed to replace the folding roofs of touring cars providing for better ...
Blanchard Auto Repair
core  

Current role of mammalian sirtuins in DNA repair [PDF]

, 2019
Cellular DNA is constantly challenged by damage-inducing factors derived from exogenous or endogenous sources. Thus, to protect against DNA damage, cells have evolved complex and finely regulated mechanisms collectively known as DNA-damage response (DDR).
Lagunas-Rangel, Francisco Alejandro,
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Making and repairing places for making and repairing

Strategic Design Research Journal, 2018
Collective DIY (do-it-yourself) is a phenomenon that is increasingly connected with struggles for autonomy. Autonomy here is seen as creating shared resources and the means of continuously steering the activities of the collective. Therefore, this article explores contemporary, collective DIY initiatives, and the relation of design and autonomy in such
openaire   +4 more sources

Self-repair ability of evolved self-assembling systems in cellular automata [PDF]

, 2014
Self-repairing systems are those that are able to reconfigure themselves following disruptions to bring them back into a defined normal state. In this paper we explore the self-repair ability of some cellular automata-like systems, which differ from ...
Johnson, Colin G., Öztürkeri, Can
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study

Clinical, Cosmetic and Investigational Dermatology
Chenyang Ge,1 Yizheng Wang,2 Xuegang Zhao,1 Jiawen Hao,1 Jing Zhang,1 Mengyuan Lu,1 Congying Li,1 Jianke Feng,1 Qingfu Zhang1 1Burn and Wound Repair Center, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050000, People’s Republic of China;
Ge C, Wang Y, Zhao X, Hao J, Zhang J, Lu M, Li C, Feng J, Zhang Q   +8 more
doaj  

RePaIR: Repaired pruning at initialization resilience

Neural Networks
Over the past decade, the size of neural network models has gradually increased in both breadth and depth, leading to a growing interest in the application of neural network pruning. Unstructured pruning provides fine-grained sparsity and achieves better inference acceleration under specific hardware support. Unstructured Pruning at Initialization (PaI)
Haocheng Zhao, Runwei Guan, Ka Lok Man, Limin Yu, Yutao Yue   +4 more
openaire   +2 more sources

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining. [PDF]

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source