Results 91 to 100 of about 1,744,271 (310)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
AerospaceThe aviation industry relies on continuous inspections to ensure infrastructure safety, particularly in confined spaces like aircraft fuel tanks, where human inspections are labor-intensive, risky, and expose workers to hazardous exposures.
Adrián Ricárdez Ortigosa +6 more
doaj +1 more source
composite biomaterials for bone repair
, 2018 The fast replacement of native functionality (i.e., biological, chemical, mechanical) of damaged skeletal tissues currently represents the main challenge of clinical surgery.
Roberto De santis +2 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study
Clinical, Cosmetic and Investigational DermatologyChenyang Ge,1 Yizheng Wang,2 Xuegang Zhao,1 Jiawen Hao,1 Jing Zhang,1 Mengyuan Lu,1 Congying Li,1 Jianke Feng,1 Qingfu Zhang1 1Burn and Wound Repair Center, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050000, People’s Republic of China;
Ge C +8 more
doaj
Making and repairing places for making and repairing
Strategic Design Research Journal, 2018 Collective DIY (do-it-yourself) is a phenomenon that is increasingly connected with struggles for autonomy. Autonomy here is seen as creating shared resources and the means of continuously steering the activities of the collective. Therefore, this article explores contemporary, collective DIY initiatives, and the relation of design and autonomy in such
openaire +4 more sources
Effective Structural Concrete Repair, Volume 3 of 3, Evaluation of Repair Materials for Use in Patching Damaged Concrete; TR-428, March 2004 [PDF]
, 2004 Structural concrete is one of the most commonly used construction materials in the United States. However, due to changes in design specifications, aging, vehicle impact, etc.
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Stem Cell Research in : Sources, Geopolitical Influence, and Transplantation
Cell Transplantation, 2010 If the rapidly progressing field of stem cell research reaches its full potential, successful treatments and enhanced understanding of many diseases are the likely results.
David J. Eve +3 more
doaj +1 more source