Results 31 to 40 of about 3,010,841 (282)
Journal of Biological Chemistry, 2015 Highly conserved MutS homologs (MSH) and MutL homologs (MLH/PMS) are the fundamental components of mismatch repair (MMR). After decades of debate, it appears clear that the MSH proteins initiate MMR by recognizing a mismatch and forming multiple extremely stable ATP-bound sliding clamps that diffuse without hydrolysis along the adjacent DNA.
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost +10 more
wiley +1 more source
Cell Transplantation, 2016 Cell transplantation is one of the most promising strategies for repair of human spinal cord injuries. Animal studies from a number of laboratories have shown that transplantation of olfactory ensheathing cells cultured from biopsies of the olfactory ...
Ying Li, Daqing Li, Geoffrey Raisman
doaj +1 more source
Increasing Availability in Distributed Storage Systems via Clustering
, 2018 We introduce the Fixed Cluster Repair System (FCRS) as a novel architecture for Distributed Storage Systems (DSS), achieving a small repair bandwidth while guaranteeing a high availability.
Gastpar, Michael, Sahraei, Saeid
core +1 more source
A Comprehensive Study of Automatic Program Repair on the QuixBugs Benchmark [PDF]
, 2019 Automatic program repair papers tend to repeatedly use the same benchmarks. This poses a threat to the external validity of the findings of the program repair research community.
Durieux, Thomas +3 more
core +4 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Online self-repair of FIR filters [PDF]
, 2003 Chip-level failure detection has been a target of research for some time, but today's very deep-submicron technology is forcing such research to move beyond detection.
Benso, Alfredo +3 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Case Reports in Dermatological MedicineAlopecia areata (AA) is an autoimmune condition with unpredictable progression, negatively impacting the quality of life. Despite various therapeutic options, refractory cases remain challenging to treat. Emerging evidence highlights the regenerative and
Mohammad Ali Nilforoushzadeh +3 more
doaj +1 more source