Results 51 to 60 of about 1,567,787 (319)
Investigation of DNA repair in human oocytes and preimplantation embryos [PDF]
, 2010 DNA repair genes are expressed in mammalian embryos and in human germinal vesicles, however, little is known about DNA repair in human preimplantation embryos.
Jaroudi, S.
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Case Reports in Dermatological MedicineHair shaft abnormalities, often linked to genetic or acquired conditions, present significant treatment challenges with limited and inconsistent therapeutic success.
Mohammad Ali Nilforoushzadeh +3 more
doaj +1 more source
Commentary: To repair or not repair—that is the question [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2021 Kanika, Kalra, Edward P, Chen
openaire +2 more sources
Locally repairable codes with multiple repair alternatives [PDF]
2013 IEEE International Symposium on Information Theory, 2013 Distributed storage systems need to store data redundantly in order to provide some fault-tolerance and guarantee system reliability. Different coding techniques have been proposed to provide the required redundancy more efficiently than traditional replication schemes.
Lluis Pamies-Juarez +2 more
openaire +2 more sources
Nuclear EGFR modulation of DNA repair [PDF]
, 2011 Overexpression of the epidermal growth factor receptor (EGFR) is associated with resistance to chemotherapy and radiotherapy. EGFR involvement, in repair of radiation-induced DNA damage, is mediated by association with the catalytic subunit of DNA ...
Liccardi, G.
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The Mechanistic Role of PPARγ in Wound Healing
PPAR ResearchThe receptor known as peroxisome proliferator-activated receptor gamma (PPARγ) is crucial for effective wound healing, and recent progress has given a deeper understanding of its complex functions.
Zhaojun Wang +5 more
doaj +1 more source
PAIN Reports, 2019 . Introduction:. Gabapentinoids are first-line treatments for painful traumatic and nontraumatic central nervous system disorders. Evidence from a large human study suggests that early use of gabapentinoids after spinal cord injury improves motor scores.
Erin L.K.S. Erskine +7 more
doaj +1 more source