Results 61 to 70 of about 3,036,040 (301)
, 2016 This paper reports on EPSRC-funded research that explores the role of repair in creating new models of sustainable business. In the lifecycle stage of repair we explore what 'broken' means and uncover the nature of local and dispersed repair activities ...
Charter, M. +6 more
core +1 more source
An Improved Outer Bound on the Storage-Repair-Bandwidth Tradeoff of Exact-Repair Regenerating Codes
, 2013 In this paper we establish an improved outer bound on the storage-repair-bandwidth tradeoff of regenerating codes under exact repair. The result shows that in particular, it is not possible to construct exact-repair regenerating codes that asymptotically
Kumar, P. Vijay +2 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Durability and service life of concrete repairs in the presence of cracks [PDF]
, 2010 Engineered Cementitious Composite (ECC) has been proposed to be one of the most promising repair materials due to its unique high ductility and tight crack width control.
van Breugel, Klaas +2 more
core
DNA charge transport as a first step in coordinating the detection of lesions by repair proteins [PDF]
, 2012 Damaged bases in DNA are known to lead to errors in replication and transcription, compromising the integrity of the genome. We have proposed a model where repair proteins containing redox-active [4Fe-4S] clusters utilize DNA charge transport (CT) as a ...
Barton, Jacqueline K. +4 more
core +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Storage codes -- coding rate and repair locality [PDF]
, 2013 The {\em repair locality} of a distributed storage code is the maximum number of nodes that ever needs to be contacted during the repair of a failed node.
Hollmann, Henk D. L.
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
TET knockout cells transit between pluripotent states and exhibit precocious germline entry
The EMBO JournalTET1, TET2 and TET3 are DNA demethylases with important roles in development and differentiation. To assess the contributions of TET proteins to cell function during early development, single and compound knockouts of Tet genes in mouse pluripotent ...
Raphaël Pantier +7 more
doaj +1 more source
Haematologica, 2019 Despite mounting evidence of a massive peripheral inflammatory response accompanying stroke, the ability of intracerebrally transplanted cells to migrate to the periphery and sequester systemic inflammation remains unexamined.
Kaya Xu +6 more
doaj +1 more source