Results 71 to 80 of about 251,710 (258)

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Nature Communications
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche.
Pranvera Sadiku, Alejandro J. Brenes, Rupert L. Mayer, Leila Reyes, Patricia Coelho, Gabi van Stralen, Ailiang Zhang, Manuel A. Sanchez-Garcia, Emily R. Watts, Imran Liaquat, Andrew J. M. Howden, Ikeoluwa Adekoya, Anuka Boldbaatar, Allan MacRaild, Sarah Risbridger, Gillian M. Morrison, Heather MacPherson, Caroline M. Bruce, Shonna Johnston, Robert Grecian, Fiona A. Murphy, Steven M. Pollard, Paul M. Brennan, Karl Mechtler, Sarah R. Walmsley   +24 more
doaj   +1 more source

Assessment of Tilapia Skin Collagen for Biomedical Research Applications in Comparison with Mammalian Collagen

Molecules
Collagen is an important material for biomedical research, but using mammalian tissue-derived collagen carries the risk of zoonotic disease transmission.
Jyun-Yuan Huang, Tzyy-Yue Wong, Ting-Yuan Tu, Ming-Jer Tang, Hsi-Hui Lin, Yuan-Yu Hsueh   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4

Nature Communications
The cell-type-specific function of transcription factors (TFs) is crucial for determining cellular identity. However, it is unclear how a single TF can function specifically in different cell types. Here, we define the molecular features that enable OCT4
Burak Ozkan, Mitzy Rios de Anda, Elisa Hall-Ponsele, Maria Rosa Portero Migueles, Amani Alshaikh, Marta Hanzevacki, Moriyah Naama, Katharine Furlong, Gareth A. Roberts, Meryam Beniazza, My Linh Huynh, Michael R. O’Dwyer, Sonia Yiakoumi, Christos Spanos, Hazar Yassen, Keisuke Kaji, Hitoshi Niwa, Yosef Buganim, Sally Lowell, Abdenour Soufi   +19 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Insights into endometriosis symptom trajectories and assessment of surgical intervention outcomes using longitudinal actigraphy

npj Digital Medicine
Endometriosis is a common, chronic condition associated with debilitating pain, fatigue, and heterogeneous symptom presentation. In this exploratory study, 68 participants with confirmed endometriosis were monitored for up to three 4–6-week smartwatch ...
Katherine Edgley, Philippa T. K. Saunders, Lucy H. R. Whitaker, Andrew W. Horne, Athanasios Tsanas   +4 more
doaj   +1 more source

Boron‐Enhanced Mitochondrial Repair: DeepA‐I Tissue Regeneration

Cellular metabolism is a key regulator of tissue repair and regeneration, with mitochondrial function playing a central role in energy production and cellular homeostasis.
Mustafa Kucukali, Onganer, Pinar Uysal, Elif Damla Arısan, Dalbayrak, Basak, Basak Dalbayrak, Beyza Yılmaz, Pinar Uysal Onganer, Kucukali, Mustafa, Ar\u131san, Elif Damla, Y\u131lmaz, Beyza   +9 more
core   +1 more source

Extracellular matrix scaffolds for cartilage and bone regeneration. [PDF]

, 2013
Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and
Benders, K.E.M., Tissue Repair, van Weeren, P.R., Badylak, S.F., Malda, J., Dhert, W.J.A., Saris, D.B.F., Saris, Daniël B.F., Dep Gezondheidszorg Paard   +8 more
core   +2 more sources

Semantic Modeling in Materials Science and Engineering With Platform MaterialDigital Core Ontology 3.0

Advanced Engineering Materials, EarlyView.
The community‐driven Platform MaterialDigital Core Ontology (PMDco) 3.0 is introduced as a Basic Formal Ontology‐aligned semantic backbone for the processing–structure–properties paradigm in Materials Science and Engineering. Modular engineering, automated releases, and validation workflows are highlighted and key semantic patterns for materials ...
Markus Schilling, Philipp von Hartrott, Jörg Waitelonis, Thomas Hanke, Henk Birkholz, Hossein Beygi Nasrabadi, Khashayar Razghandi, Kamilla Zaripova, Felix Thonagel, Fabian Neuhaus, Martin Glauer, Lars Vogt, Harald Sack, Lutz Mädler, Bernd Bayerlein, Chris Eberl   +15 more
wiley   +1 more source