Results 71 to 80 of about 18,549 (301)

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Pregnancy Rates in Repeat-breeder Heifers Following Multiple Artificial Inseminations during Spontaneous Oestrus

Acta Veterinaria Scandinavica, 2005
Hormonal asynchronies during oestrus, related to the presence of suprabasal plasma-progesterone (P4) concentrations and a delayed ovulation, interfere with the fertility of repeat-breeder heifers (RBH).
Rodríguez-Martínez Heriberto, Båge Renée, Saravia Fernando, Singh Bhupender   +3 more
doaj   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Clinical Approach to the Repeat Breeder Cow Syndrome [PDF]

, 2012
Dairy cattle production requires great intensification, which has been demonstrated to affect negatively on the reproduction. One calf by cow and year is the reproductive objective in these animals. It means that cows must get pregnant after AI, maintain the pregnancy, have parturition after 270 days approx., and wait for a period of 40-50 days to be ...
Perez-Marin, Carlos C., Moreno, Laura Molina, Calero, Guillermo Vizuete   +2 more
openaire   +2 more sources

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

PHYSICAL CHARACTERISTICS OF OESTRUS MUCUS AND CONCEPTION RATES IN REPEAT BREEDER BUFFALOES

Pakistan Veterinary Journal, 2002
A project was planned to study some physical characteristics of oestrus mucus and conception rates in repeat breeder buffaloes after different treatments. For this purpose 60 adult buffaloes with history of repeat breeding were used.
H.A. Samad. S.M. Iqbal Shah. Nazir Ahmad and Nafees Akhtar
doaj   +2 more sources

Major reproductive health problems of indigenous Borena cows in Ethiopia

Journal of Advanced Veterinary and Animal Research, 2014
The study was conducted to identify the major reproductive health problems and its associated risk factors in indigenous Borena breed cows in Borena zone in Southern Ethiopia between September 2013 and February 2014.
Ararsa Duguma Benti, Wubishet Zewdie
doaj   +1 more source

Repeat Breeder Syndrome Therapies in Dairy Cows: A Review

Reproduction in Domestic Animals
ABSTRACTRepeat breeder (RB) cows are clinically healthy animals with regular oestrous cycles that do not become pregnant after three or more services. This syndrome has an incidence ranging between 10.1% and 24%. Repeat breeder syndrome (RBS) in dairy cows leads to economic losses to dairy farmers by increasing the calving interval and consequently ...
Alice Carbonari, Matteo Burgio, Lorenza Frattina, Vincenzo Cicirelli, Annalisa Rizzo   +4 more
openaire   +3 more sources

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Relationship between clinical and postmortem evaluation in repeat breeder beef cows Relação entre características clínicas e post-mortem em vacas de corte repetidoras de serviço

Ciência Rural, 2008
The objective of this study was to investigate the causes of the repeat breeder syndrome comparing clinical signs and postmortem findings in beef cows.
Rogério Ferreira, João Francisco Coelho de Oliveira, Alfredo Quites Antoniazzi, Cláudio Alves Pimentel, José Carlos Ferrugem Moraes, Luiz Ernani Henkes, Vilceu Bordignon, Paulo Bayard Dias Gonçalves   +7 more
doaj   +1 more source