Results 41 to 50 of about 65,635 (300)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Cooperative routing algorithm based on game theory
Tongxin xuebao, 2013 Cooperative virtual multiple-input multiple-output (VMIMO) transmission is an effective technique to im-prove the transmission performance of wireless network. By taking advantage of diversity gain of VMIMO, the cross-layer VMIMO routing design combining
Kun XIE +3 more
doaj +2 more sources
Decentralized Trust Management and Incentive Mechanisms for Secure Information Sharing in VANET
IEEE AccessThe information sharing among internet-connected vehicles is close, but there may be the issue of vehicles providing false information. This paper proposes a new incentive mechanism scheme for VANET to provide a decentralized and trusted service ...
Hongmu Han +4 more
doaj +1 more source
Coopetition in Intermodal Freight Transport Services
Discrete Dynamics in Nature and Society, 2015 The paper studies the coopetition of the downstream different carriers by providing complementary transport services in intermodal freight transport chain.
Jian Liu, Yinzhen Li, Jun Li
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Games, 2016 In strategic situations, humans infer the state of mind of others, e.g., emotions or intentions, adapting their behavior appropriately. Nonetheless, evolutionary studies of cooperation typically focus only on reaction norms, e.g., tit for tat, whereby ...
Mitsuhiro Nakamura, Hisashi Ohtsuki
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Study on game-based incentive mechanism of mobile ad hoc network
Tongxin xuebao, 2014 According to the selfishness of rational mobile ad hoc network nodes showed during the packet forwarding, the selfish behavior statically and dynamically based on game theory were analyzed and modeled.
Ying-you WEN, Bo ZHAO, Hong ZHAO
doaj +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source