Results 301 to 310 of about 1,635,028 (357)

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

Advanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox, Melanie Burke, Sara Milani, Matthew A White, Fergal M Waldron, Dorothea Böken, Evgeniia Lobanova, Jemeen Sreedharan, Jenna M Gregory, David Klenerman   +9 more
wiley   +1 more source

Academic achievement helps coordination on mutually advantageous outcomes. [PDF]

Proc Natl Acad Sci U S A
Brocas I, Carrillo JD.
europepmc   +1 more source

Electron Transfer‐Tailored D‐Band Center to Boost Nanozyme Catalysis for Interpretable Machine Learning‐Empowered Intelligent Biosensing

Advanced Science, EarlyView.
This study pioneers a rational nanozyme design strategy guided by electron transfer mechanisms while advancing biosensing paradigms through interpretable machine learning‐enhanced signal intelligence. By transforming biosensors from passive transducers to active diagnostic systems, this work establishes a versatile framework for addressing global ...
Yuechun Li, Chenxin Ji, Zhaowen Cui, Jianxing Feng, Liang Zhang, Sha Liu, Wentao Zhang, Yanwei Ji, Yizhong Shen, Jianlong Wang   +9 more
wiley   +1 more source

Effectiveness of cognitive remediation in subjects with major depressive disorder: A multicenter randomized controlled study in a real-world setting. [PDF]

Eur Psychiatry
Barlati S, Nibbio G, Bellomo A, Carpiniello B, Colombo C, De Giorgi S, Deste G, Maina G, Martinotti G, Tortorella A, Di Salvo G, Luciano M, Pinna F, Ventriglio A, Fiorillo A, Vita A, CogRemMDD Study Group.   +16 more
europepmc   +1 more source

Painting Peptides With Antimicrobial Potency Through Deep Reinforcement Learning

Advanced Science, EarlyView.
AMPainter is a powerful design model for ’painting’ the antimicrobial potency on any given peptide sequence, based on the strategy of virtual directed evolution and deep reinforcement learning. Abstract In the post‐antibiotic era, antimicrobial peptides (AMPs) are considered ideal drug candidates because of their lower likelihood of inducing resistance.
Ruihan Dong, Qiushi Cao, Chen Song
wiley   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

A systematic review and content analysis of serious video games for children with ADHD. [PDF]

Front Psychiatry
Schultz BK, Evans SW, Carter KM, Dembowski A, Lojinger K, Murray ER, Walcott C.   +6 more
europepmc   +1 more source

Chronically Stable, High‐Resolution Micro‐Electrocorticographic Brain‐Computer Interfaces for Real‐Time Motor Decoding

Advanced Science, EarlyView.
A high‐resolution micro‐electrocorticographic (µECoG) brain‐computer interface (BCI) for real‐time motor decoding is reported. The application of flexible, scalable µECoG electrode arrays overcomes the insufficient spatial resolution in conventional ECoG BCIs.
Erda Zhou, Xiner Wang, Jizhi Liang, Yang Liu, Qinrong Yang, Xingchen Ran, Lei Xia, Xiang Zou, Changjiang Liu, Liuyang Sun, Lei Peng, Liang Chen, Ying Mao, Zehan Wu, Tiger H. Tao, Zhitao Zhou   +15 more
wiley   +1 more source

A Novel Approach Using Serious Game Data to Predict the WISC-V Processing Speed Index in Children With Attention-Deficit/Hyperactivity Disorder: Machine Learning Study.

JMIR Serious Games
Kim JS, Jeong YJ, Kim SJ, Jun SJ, Park JY, Hoe HS, Song JH.   +6 more
europepmc   +1 more source

Adherence to different types of sports shapes motor competence development in preschool children. [PDF]

Sci Rep
Guo X, Li C, Zhao J, Yang W, Xu Q, Kawczyński A, Clemente FM.   +6 more
europepmc   +1 more source