Results 101 to 110 of about 861,022 (290)

Retardation effects due to overloads in aluminium-alloy aeronautical components [PDF]

open access: yes, 2017
Fatigue data are generally derived under constant-amplitude loading conditions, but aircraft components are subjected to variable-amplitude loading. Without interaction effects, caused by overloads and underloads intermingled in a loading sequence, it ...
Armentani   +21 more
core   +4 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Experimental investigation of concrete fatigue resistance [PDF]

open access: yes, 2014
A lack of knowledge on the fatigue resistance of self-compacting concrete (SCC) structures has led to the research presented in this paper. Several reinforced concrete beams were subjected to both static and cyclic four-point bending tests in order to ...
Boel, Veerle   +3 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Experimental and Numerical Investigation of High Strength Reinforced Concrete Deep Beams with Web Openings under Repeated Loading

open access: yesمجلة النهرين للعلوم الهندسية, 2017
This paper presents experimental investigations to study the behavior of High Strength Reinforced Concrete (HSRC) deep beams with web openings under monotonic and static repeated loading conditions.
Ihsan A. S. Al-Shaarbaf   +2 more
doaj  

Influence of Stirrup-Tie Shape on Inelastic Cyclic Response of Flanged Reinforced Concrete Flexural Members [PDF]

open access: yes, 1981
Three reinforced concrete flanged sections (T-sections) having different shapes of shear reinforcement were subjected to cyclic inelastic flexure representative of what framed structure members might-be forced to endure during a severe earthquake. The
Scribner, C.F., Wilhelm, D.R.
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

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