Results 81 to 90 of about 1,652,346 (296)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Mechanical Response of Epoxy Resin-Flax Fiber Composites Subjected to Repeated Loading and Creep Recovery Tests. [PDF]
Polymers (Basel), 2023 Stochioiu C, Hadăr A, Piezel B.
europepmc +1 more source
Journal of Materials and Engineering StructuresThe present research work, presented the results of eight drop-in-ends specimens tested experimentally to investigate the efficiency of the NSM steel bars technique in strengthening the drop-in-ends including internal miss detailing, under static and ...
Qasim Muhammed SHAKIR, Ruqyia ALLIWE
doaj
Impact of repeated loading on mechanical response of a reinforced sand
Journal of Rock Mechanics and Geotechnical Engineering, 2019 Pavements constructed over loosely compacted subgrades may not possess adequate California bearing ratio (CBR) to meet the requirements of pavement design codes, which may lead to a thicker pavement design for addressing the required strength ...
Aida Mehrpazhouh +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Evaluating Flexural Performance of Repaired Reinforced Concrete Beams under Static and Repeated Loading Using Non-Destructive Methods. [PDF]
Materials (Basel), 2022 Wang B, Gupta R.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Influence of Mechanical Damage under Repeated Loading on the Resistance of Geogrids against Abrasion. [PDF]
Materials (Basel), 2021 Carlos DM +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022 Introduction: Evaluating the frequency of complications in implant supported prosthesis such as screw loosening and porcelain fracture is important for prevention and management of these problems.
Mahnaz Hatami +2 more
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