Results 81 to 90 of about 541,606 (211)
Constitutive Equations for Use in Design Analyses of Long-life Elevated Temperature Components [PDF]
, 1983 Design analysis needs and procedures relative to elevated temperature components in liquid metal fast breeder reactor (LMFBR) system were examined. The effects of the thermal transients on the pressure boundary components are enhanced by the excellent ...
Pugh, C. E., Robinson, D. N.
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Resilient Modulus Characterization of Alaskan Granular Base Materials [PDF]
, 2010 INE/AUC 11 ...
Li, Lin, Liu, Juanyu, Zhang, Xiong
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Push-and-Twist Drillstring Assemblies [PDF]
, 2017 Deep drilling using a rigid drillstring requires the assembly and disassembly of multiple drill pipes. The interfaces between these pipes provide a challenge for automation because they must transmit large drilling forces and movements while, at the same
Firstbrook, David G. +5 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Поліпшення пластичних властивостей високоміцних двофазних титанових сплавів за рахунок ударно-коливального навантаження [PDF]
, 2017 It is established experimentally that dynamic non-equilibrium processes (DNP) with self-organizing structure occur under impact-oscillatory loading in high-strength two-phase titanium alloys VT22 and VT23.
Марущак, Павло Орестович +2 more
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source