Results 61 to 70 of about 357,221 (262)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tensile and Tearing Properties of a Geocomposite Mechanically Damaged by Repeated Loading and Abrasion. [PDF]

Materials (Basel), 2023
Carneiro JR, Almeida F, Carvalho F, Lopes ML.   +3 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Finite Element Analysis of Voided Reinforced Concrete Slabs Enhanced by GFRP Sheets under Monotonic and Repeated Loads

Journal of Engineering
Six (1000*1000 mm2) slab specimens were cast and tested as two-way simply supported slabs previously (three under monotonic loading and three under repeated loading) are used in this research.
Shahad H. Mtashar, Adel A. Al-Azzawi
doaj   +1 more source

Behavior Under Repeated Loading of RC Beams Externally Strengthened in Flexure with SRG Systems. [PDF]

Materials (Basel), 2023
Bencardino F, Nisticò M.
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Experimental and modelling buckling of wood-based columns under repeated loading

EPJ Web of Conferences, 2010
Collapse of timber constructions can appear under the effect of load that exceeds the resistance of a carrying element or under the effect of a geometrical instability like buckling.
Nafa Z., Chaplain M., Bouras F.
doaj   +1 more source

Mechanical Response of Epoxy Resin-Flax Fiber Composites Subjected to Repeated Loading and Creep Recovery Tests. [PDF]

Polymers (Basel), 2023
Stochioiu C, Hadăr A, Piezel B.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Strength of welded joints in class A500C reinforcing bars under low-cycle repeated loads

Будівельні конструкції. Теорія і практика
For more than 25 years now, A500C class reinforcement has been the most widely used in reinforced concrete structures. The introduction of class A500C reinforcement has been accompanied by extensive research into its mechanical properties, bond with ...
Yulii Klymov
doaj   +1 more source