Results 51 to 60 of about 1,652,346 (296)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Bond Behavior Between Steel Bar and Reactive Powder Concrete Under Repeated Loading

Buildings
To investigate the influence of repeated loading on the bond behavior between steel bars and reactive powder concrete (RPC), this study conducted repeated loading tests on eight beam specimens and one static loading test as a control.
Dewen Zhang, Yanming Feng, Ruihui Han, Xiangsheng Kong, Dehong Wang, Chao Ren   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Repeated Loading of Normally Consolidated Clay [PDF]

, 1970
The effects of repeated loading on a normally consolidated,saturated silty clay, are compared to the effects of sustained loading and standard strength tests on the same material.
Greenwood, John Robert
core   +1 more source

A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration

Biomolecules & Biomedicine
Mechanical stress has been viewed as one of the key risk factors in accelerating the intervertebral disc degeneration process. The goal of the present study was to employ a repeated strike loading bovine caudal disc system to elucidate the ...
Baoliang Li, Xu Chen, Hongkun Chen, Fu Zhang, Jianfeng Li, Zhengya Zhu, Tao Tang, Manman Gao, Nianhu Li, Liang Ma, Zhiyu Zhou   +10 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multivariate Prediction Model of Strength and Acoustic Emission Energy considering Parameter Correlation of Coal or Rock

Advances in Materials Science and Engineering, 2020
Due to the heterogeneity of the internal structure and the different external loading conditions, the mechanical and acoustic emission (AE) characteristic parameters of coal and rock are discrete in the process of loading until failure, and many repeated
Shuncai Li, Daquan Li, Nong Zhang
doaj   +1 more source

Mechanical Behavior of Q460 High-Strength Steel under Low-Cycle Fatigue Loading

Advances in Civil Engineering, 2022
To investigate the mechanical properties of Q460 high-strength steel under repeat tensile loading, 45 specimens were prepared for repeated tensile tests. The specimens are tested under 16 different loading regimes.
Xue Han, Min Chang, Haifeng Li, Hualin Cao, Baoan Cao   +4 more
doaj   +1 more source

Acute Cardiorespiratory Responses to Inspiratory Pressure Threshold Loading [PDF]

, 2010
Purpose: We tested the acute responses to differing pressure threshold inspiratory loading intensities in well-trained rowers. The purpose of this study was to evaluate 1) how the magnitude of inspiratory pressure threshold loading influences repetition ...
Griffiths, L.A., Griffiths, Lisa, McConnell, A.K., Griffiths, LA   +3 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source