Results 41 to 50 of about 541,606 (211)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Fracture simulation for zirconia toughened alumina microstructure [PDF]
, 2013 Purpose - The purpose of this paper is to describe finite element modelling for fracture and fatigue behaviour of zirconia toughened alumina microstructures. Design/methodology/approach - A two-dimensional finite element model is developed with an actual
Forest, Bernard +2 more
core +7 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Repeated loading and damage progression in cerebral arteries
Acta BiomaterialiaTraumatic brain injury poses a major public health challenge with significant immediate and long-term effects. Repetitive head trauma is an ongoing area of research, and little is known about the response of cerebral blood vessels to such loading.
Farshid Shojaeianforoud +5 more
openaire +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Structural relaxation in amorphous materials under cyclic tension-compression loading
, 2019 The process of structural relaxation in disordered solids subjected to repeated tension-compression loading is studied using molecular dynamics simulations.
Jana, Pritam Kumar, Priezjev, Nikolai V.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
One-dimensional compression of a crushable sand in dry and wet conditions [PDF]
, 2015 This paper presents the results of a series of dry and wet one-dimenional compression tests on a calcareous sand from the Persian Gulf. Calcareous grains crush more easily compared to silica grains, a fact that is mainly attributed to their angular shape
Haegeman, Wim +2 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On the physical correlations of the thermoplasticity deformation theory [PDF]
, 2012 Розглянуто узагальнення деформаційної теорії термопластичності при неізотермічних процесах навантаження з урахуванням можливого пружного розвантаження після пластичного деформування, повторного пластичного деформування після пружного розвантаження і ...
Holovatyy, B. +3 more
core