Results 91 to 100 of about 1,652,346 (296)

The Breathing of Webs Under Repeated Partial Edge Loading [PDF]

, 2012
Slender webs subjected to many times repeated partial edge loading repeatedly buckle (breathe) under this loading, which brings about the initiation and propagation of fatigue cracks in the neighbourhood of the loaded flange.
Škaloud, M., Urushadze, S., Zörnerová, M.   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Experimental and Numerical Investigation of High Strength Reinforced Concrete Deep Beams with Web Openings under Repeated Loading

مجلة النهرين للعلوم الهندسية, 2017
This paper presents experimental investigations to study the behavior of High Strength Reinforced Concrete (HSRC) deep beams with web openings under monotonic and static repeated loading conditions.
Ihsan A. S. Al-Shaarbaf, Ahmed s. Ali, Abdulkhalik J. Abdulridha   +2 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Folk Theorem in Dynastic Repeated Games [PDF]

A canonical interpretation of an infinitely repeated game is that of a “dynastic” repeated game: a stage game repeatedly played by successive generations of finitely-lived players with dynastic preferences.
Roger Lagunoff, Dino Gerardi, Luca Anderlini   +2 more
core   +2 more sources

Purification in the Infinitely-Repeated Prisoners' Dilemma [PDF]

This paper investigates the Harsanyi (1973)-purifiability of mixed strategies in the repeated prisoners' dilemma with perfect monitoring. We perturb the game so that in each period, a player receives a private payoff shock which is independently and ...
V. Bhaskar, George J. Mailath, Stephen Morris   +2 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Finite Element Analysis of the Flexural Performance of Hybrid (Steel-BFRP) RC Beams under Repeated Loading: Verification and Parametric Investigation

Journal of Engineering
The corrosion of steel bars in reinforced concrete structures subjected to harsh environments remains a significant challenge. Fiber-reinforced polymer (FRP) composites have been investigated as potential alternatives to conventional steel reinforcement.
Shahad Jawad Kadhim, Hassan Falah Hassan   +1 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Finitely repeated games with semi-standard monitoring [PDF]

This paper studies finitely repeated games with semi-standard monitoring played in pure strategies. In these games, each player's action set is endowed with a partition, and the equivalence classes of the actions played are publicly observed.
Tristan Tomala, Pauline Contou-Carrère
core