Results 101 to 110 of about 1,652,346 (296)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Repeated median and hybrid filters [PDF]
Standard median filters preserve abrupt shifts (edges) and remove impulsive noise (outliers) from a constant signal but they deteriorate in trend periods.
Fried, Roland +2 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
RESPONSE OF LACED REINFORCED CONCRETE BEAMS SUBJECTED TO REPEATED LOADING
Journal of Engineering and Sustainable Development, 2018 In this research, the structural behavior of Laced Reinforced Concrete T-beam of cross sectional dimensions (300mm × 80mm) flange and (150mm × 220mm) web under monotonic loadings was studied experimentally.
Abbas AbdulMajeed Allawi +1 more
doaj
Cracking characteristics of corroded RC beams under repeated loading
, 2011 The cracking characteristics of corroded reinforced concrete (RC) beams under repeated loading were experimentally studied. A total of 15 test specimens (three non-corroded and 12 corroded RC beams) were investigated.
Congqi Fang, Shuai Yang
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Repeated Load Permanent Deformation Behavior of Mixes With and Wihtout Modified Bituments [PDF]
Mehran University Research Journal of Engineering and Technology, 2011 Premature rutting in flexible pavement structure is being observed on most of the road network of Pakistan. It initiates primarily due to uncontrolled axle loading and high ambient temperatures.
Imran Hafeez, Mumtaz Ahmed Kamal
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source